Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Phytotherapy Research : PTR
Firoj AhmedMasami Ishibashi

Abstract

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.

References

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Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vaqar Mustafa AdhamiHasan Mukhtar
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Feb 15, 2008·Medicinal Research Reviews·Masami Ishibashi, Takashi Ohtsuki

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Citations

Jul 8, 2010·Journal of Natural Medicines·Firoj AhmedMasami Ishibashi
Feb 3, 2016·Chemical & Pharmaceutical Bulletin·Firoj Ahmed, Masami Ishibashi
Jan 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Otemberg Souza ChavesMaria de Fátima Vanderlei de Souza
Jul 11, 2020·Anatomy & Cell Biology·Adeshina O AdekeyeAdedamola Adediran Fafure

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis