Cryptomerione induces Th1 cell polarization via influencing IL-10 production by cholera toxin-primed dendritic cells

European Journal of Pharmacology
Masao TakeiToshihiro Hashimoto

Abstract

Dendritic cells play an important role in the initiation and regulation of immune response. Dendritic cells have a key influence in the differentiation of naïve T cells into Th1, Th2 or Th17 effector cells. Cryptomerione is terpene isolated from the heartwood of Cryptomeria japonica. In this study, we investigated the effects of Cryptomerione on the phenotypic and functional maturation of human monocyte-derived dendritic cells in vitro. Human monocytes were exposed to either Cryptomerione alone, or in combination with lipopolysaccaride (LPS) or cholera toxin (CT) and thereafter co-cultured with naïve T cells. We found no enhanced CD1a, CD80, CD83, CD86 and HLA-DR expression on Cryptomerione-primed dendritic cells. However, Cryptomerione augmented T cell stimulatory capacity in an allogeneic mixed lymphocyte reaction to CT-primed dendritic cells and influenced the production of interleukin (IL)-10 and IL-12p70 by CT-primed dendritic cells, but not LPS-primed dendritic cells. Cryptomerione also inhibited Th2 cell polarization induced by CT-primed dendritic cells, but enhanced IFN-gamma secretion by naïve T cells co-cultured with CT-primed dendritic cells. Cytokine production by CT-primed dendritic cells alone, or in combination w...Continue Reading

References

Jan 1, 1994·Annual Review of Immunology·S Romagnani
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 4, 1999·International Archives of Allergy and Immunology·G DelespesseM Sarfati
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezSebastian Amigorena
Jan 9, 2003·Current Opinion in Cell Biology·James D Orth, Mark A McNiven
Jun 13, 2003·Pathologie-biologie·R M Steinman
Mar 3, 2004·Chemical & Pharmaceutical Bulletin·Shigenobu AriharaKazuko Yoshikawa
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Oct 6, 2005·Biochemical and Biophysical Research Communications·Masao TakeiShigenobu Arihara
Nov 9, 2005·The Journal of Experimental Medicine·Tomoki ItoYong-Jun Liu
Apr 25, 2006·European Journal of Pharmacology·Masao TakeiShigenobu Arihara
Jun 15, 2006·Journal of Cell Science·Ann P WheelerAnne J Ridley
Mar 13, 2008·Biochemical and Biophysical Research Communications·Masao TakeiToshihiro Hashimoto
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Belén Blázquez, M Cecilia Berin
Dec 17, 2008·Annals of the New York Academy of Sciences·Gustavo J MartinezChen Dong

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