Cryptosporidiosis: clinical features and diagnosis.

Critical Reviews in Clinical Laboratory Sciences
L S Garcia, W L Current

Abstract

Cryptosporidiosis is an infectious disease caused by the coccidian parasite Cryptosporidium spp. that primarily infects the gastrointestinal tract of animals. Prior to late 1982, only 11 cases of human infection had been reported, with the first human case reported in 1976. During the 1980s, the number of human cases began to rise dramatically. Most of these patients were immunodeficient, many of whom had the acquired immune deficiency syndrome (AIDS). Immunocompetent individuals can also acquire the infection with mild-to-severe diarrhea lasting from several days to weeks. Immunocompromised patients develop severe, irreversible diarrhea, often thought to be a significant contributing factor leading to death. Although many therapeutic compounds have been tried, none have proven to be very successful. The incidence of this infection is worldwide, with many published reports of infection in both immunodeficient and immunocompetent individuals. The diagnostic approach has been expanded to include stool examinations using modified acid fast procedures and fluorescent monoclonal antibody reagents. Although histological methods are still routinely used for biopsy specimens, the examination of stool has proven to be a very effective, ...Continue Reading

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