Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice.

Infection and Immunity
W R Waters, J A Harp

Abstract

Mice deficient in either alpha beta or gamma delta T cells were more susceptible to infection with the protozoan parasite Cryptosporidium parvum than were control mice. Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infection. Gamma delta-T-cell-deficient neonatal mice were more susceptible than control mice but were able to clear the infection. Adult gamma delta-T-cell-deficient mice were not susceptible to infection. These data indicate that alpha beta T cells are important for resistance to C. parvum while gamma delta T cells have a less critical role.

References

Sep 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W K BornR L Modlin
Apr 1, 1990·Infection and Immunity·B L UngarF D Finkelman
Jun 16, 1989·Science·M R Capecchi
Mar 1, 1984·Infection and Immunity·J HeineD B Woodmansee
Oct 1, 1995·European Journal of Immunology·C H LadelS H Kaufmann
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KomanoS Itohara
Aug 1, 1994·Current Opinion in Immunology·S H Kaufmann
Aug 1, 1993·Current Opinion in Immunology·P C Doherty
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TsujiS Tonegawa

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Citations

Dec 22, 1999·Infection and Immunity·S M Singer, T E Nash
Mar 27, 2003·Nature Reviews. Immunology·Adrian Hayday, Robert Tigelaar
Oct 18, 2006·Parasite Immunology·C S Subauste
Oct 28, 2011·Expert Review of Anti-infective Therapy·Vincent McDonald
Jun 2, 1997·The Journal of Experimental Medicine·R SciammasJ A Bluestone
Dec 21, 2000·Parasite Immunology·V McDonald
Feb 4, 2003·Clinical and Experimental Immunology·M AoyagiY Kohno
May 23, 2003·The Journal of Parasitology·Wangxue ChenAllen G Harmsen
Jul 30, 2003·Animal Health Research Reviews·James A Harp
Oct 18, 2006·Parasite Immunology·T Evering, L M Weiss
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·A C HaydayE Ramsburg
Jun 23, 2009·European Journal of Immunology·Deena L GibbonsAdrian C Hayday
Apr 22, 2011·The Journal of Parasitology·Steven P O'HaraNicholas F LaRusso
Aug 13, 2017·Veterinary Research·Sarah ThomsonElisabeth A Innes
Sep 2, 1998·International Journal for Parasitology·M S Abrahamsen
Oct 9, 1999·Clinical Microbiology Reviews·D P Clark
Jul 24, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Eman S El-WakilAsmaa M F Al-Ghandour
Sep 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Howayda Said Fouad MoawadAmira Abd El-Lateef Saleh Ali

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