Cryptosporidium species in immunodeficient and immunocompetent patients of Valparaíso: a descriptive study

Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología
Patricia Neira OCarlos Henríquez R

Abstract

Genetical characterization of human Cryptosporidium isolates to determine species diversity. A cross-sectional study in Valparaiso, Chile, was performed. A total of 458 patients participated in the study: 259 immunodeficient (HIV, cancer, renal transplant hyper-IgM syndrome, HIV and unintended pregnancy) and 178 immunocompetent individuals provided stool samples and 21 patients bile samples. We obtained 29 (6.3%) positive samples. 25 (9.7%) derived from immunodeficient patients: 18 (7.3%) from HIV patients and 7 from patients with other immunodeficiencies. The remaining 4 (2.2%) samples originated from immunocompetent individuals. Cryptosporidium genotyping was performed by nested polymerase chain reaction (PCR) and restriction fragments length polymorphism and/or PCR followed by sequencing of the SSU rRNA from oocysts in stool samples. 4 species were identified: C. parvum, C. hominis, C. muris, and C. meleagridis. In immunodeficient patients, 16 C. parvum, 8 C. hominis, and 1 C. muris strain were identified. In immunocompetent participants, 3 C. hominis and 1 C. meleagridis isolate were found. The results indicate that zoonotic and anthroponotic transmission occurs and that C. parvum is the predominant species in our study pop...Continue Reading

Citations

Jul 28, 2016·Parasite Immunology·U RyanA Paparini
Oct 15, 2014·The American Journal of Tropical Medicine and Hygiene·Cynthia L ChappellSaul Tzipori
Aug 8, 2019·Vector Borne and Zoonotic Diseases·Francisco Ramírez-PizarroCarlos Landaeta-Aqueveque

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