Crystal-induced arthritis: an overview

The American Journal of Medicine
H R Schumacher

Abstract

The most common crystal-related arthropathies-gout, calcium pyrophosphate dihydrate disease or "pseudogout," and calcific periarthritis/tendinitis-may be appropriately diagnosed and managed by the primary care physician. Definitive diagnosis via synovial tap is recommended, as the clinical picture may not identify some cases. The acute pain and swelling of attacks, regardless of etiology, generally respond to treatment with nonsteroidal anti-inflammatory drugs and local or occasionally systemic corticosteroids. Once a causative crystal has been identified and a diagnosis established, a plan for long-term management and prevention of recurrences may be devised. Thus, uric-acid-lowering therapy may be indicated in a patient who has experienced recurrent attacks of gout, whereas control of serum phosphate levels might be effective in some individuals with hyperphosphatemia and hydroxyapatite-associated periarthritis or arthritis. Crystal deposits in joints can be destructive as well as painful. Treatment, therefore, has two objectives: To relieve the pain of the acute attack, thus restoring normal function, and to prevent the accumulation of crystals that can lead to degenerative disease. Identification and subsequent treatment of...Continue Reading

References

May 1, 1976·Arthritis and Rheumatism·D J McCarty
Dec 1, 1967·The American Journal of the Medical Sciences·T F Yü, A B Gutman
Sep 30, 1993·The New England Journal of Medicine·D G Baker, H R Schumacher
Mar 1, 1961·Annals of Internal Medicine·D J MCCARTY, J L HOLLANDER
May 1, 1963·Annals of the Rheumatic Diseases·D ZITNAN, S SIT'AJ

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Citations

Apr 8, 2010·Arthritis Research & Therapy·Michael A BeckerChristopher Lademacher
Jan 13, 2009·The Journal of Hand Surgery·Mark C WilczynskiCharles A Goldfarb
Nov 8, 2006·Primary Care·Erinn E Maury, Raymond H Flores
May 24, 2006·Rheumatic Diseases Clinics of North America·Nancy Joseph-RidgePatricia MacDonald
Feb 22, 2005·Computer Methods and Programs in Biomedicine·Ekta N ShahBruce M Rothschild
Jun 26, 2007·Current Medical Research and Opinion·Sandra NavarraAndrew M Tershakovec
Nov 2, 2005·Expert Opinion on Pharmacotherapy·Gregory Choy
Aug 3, 2006·Scandinavian Journal of Rheumatology·T K Hoskison, R L Wortmann
Dec 11, 2003·The Journal of Veterinary Medical Science·Nandadeva LokugamageIkuo Takashima
Dec 12, 2013·Seminars in Arthritis and Rheumatism·Labib I FaruqueMarcello Tonelli
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Naomi Schlesinger
Mar 31, 2004·Radiologic Clinics of North America·Johnny U V Monu, Thomas L Pope
Jun 1, 1997·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S L FilanM A Tonkin
Sep 5, 2002·Arthritis and Rheumatism·Fernando Perez-RuizAna Ruibal
Sep 8, 2006·Drugs·Gim Gee TengKenneth G Saag
Oct 2, 2007·Arthritis and Rheumatism·Fernando Perez-Ruiz, Frédéric Lioté
Feb 8, 2019·Current Topics in Medicinal Chemistry·Neelam MalikAnurag Khatkar
Apr 17, 2008·Scandinavian Journal of Rheumatology·F Perez-Ruiz, N Schlesinger
Aug 9, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shu-Jung WangYing-Chin Ko
Dec 2, 2009·Immunology and Cell Biology·Oana Popa-Nita, Paul H Naccache
Jan 23, 2019·Current Rheumatology Reviews·Emanuele ChisariWasim Khan
May 15, 2020·Chinese Medical Journal·Xiao-Jun WangJing Xiao
Aug 2, 2019·Clinical Rheumatology·Juan WangHejian Zou
Mar 29, 2011·Hospital Practice·Kathleen E Brennan, Brian J McGrory
Oct 1, 2016·JBJS Case Connector·Ryan KrochakHoward Goodman
Apr 22, 2008·The Cochrane Database of Systematic Reviews·H J E M JanssensE H Van de Lisdonk
May 14, 2021·Frontiers in Cell and Developmental Biology·Franziska MeyerJessica Bertrand
Jul 16, 2003·Clinical Therapeutics·Karissa Y KimSheldon X Kong

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