Crystal-induced neutrophil activation

Immunology and Cell Biology
Oana Popa-Nita, Paul H Naccache

Abstract

Monosodium urate (MSU) crystals are among the most potent pro-inflammatory stimuli and an innate immune inflammatory response to the crystal surface is intimately involved in the pathology of gouty arthritis. The responses of human neutrophils to MSU crystals represent an integral part of this innate response and a key component of the acute inflammatory response associated with gout. A significant, though incomplete, body of information concerning the implication of human neutrophils in MSU crystal-induced inflammation and the signal transduction pathways activated in response to these agonists in neutrophils has accumulated over the last few years. This review focuses on the current state of knowledge concerning the activation of human neutrophils by MSU crystals specifically in the context of acute gout, as recent data begin to draw a comprehensive picture of the events leading to the often excessive functional responses of neutrophils to these particulate agonists. A non-exhaustive list of the most important questions that remain to be assessed to further describe the physio-pathological mechanisms of gouty arthritis is presented here.

References

Oct 25, 1975·Lancet·N Matsumura, Y Mizushima
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R L Margolis, L Wilson
Feb 1, 1976·Biochemical Pharmacology·R J Flower, G J Blackwell
Nov 1, 1977·Arthritis and Rheumatism·M H GinsbergJ L Skosey
Jul 1, 1975·Archives of Dermatology·R J Coskey
Jan 15, 1976·The New England Journal of Medicine·D ZemerJ Gafni
Nov 1, 1990·The Journal of Cell Biology·W T MattenP F Maness
Sep 1, 1991·Agents and Actions·C J RobergeP E Poubelle
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·F GuadagniJ W Greiner
Dec 1, 1988·Clinical Biochemistry·A K Bhatt, I Spilberg
Sep 30, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·K D Brandt
Jul 1, 1966·The Journal of Experimental Medicine·P Phelps, D J McCarty
Nov 20, 1982·Lancet·S A RaeM J Smith
Feb 1, 1982·Arthritis and Rheumatism·S AbramsonG Weissmann
May 1, 1982·Peptides·T L O'Donohue, D M Dorsa
Jun 1, 1984·The Journal of Clinical Investigation·R TerkeltaubM H Ginsberg
May 1, 1982·Arthritis and Rheumatism·B C Jaques, M H Ginsberg
Oct 1, 1993·The Journal of Clinical Investigation·C J RobergeP H Naccache
Feb 1, 1995·The Journal of Experimental Medicine·T C van der Pouw KraanL A Aarden
Feb 26, 1996·The American Journal of Medicine·H R Schumacher
Mar 1, 1997·Immunology Today·J M Lipton, A Catania
Feb 24, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F BarabéP H Naccache
May 16, 1998·The Journal of Experimental Medicine·L OehlerW Knapp
Aug 26, 1998·Biochemical and Biophysical Research Communications·S MiyatakeT Saito
Jan 12, 1999·The Biochemical Journal·J MarcilS Bourgoin

❮ Previous
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Citations

Dec 21, 2013·Current Rheumatology Reports·Melissa L FernandezGary K Shooter
Feb 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Evan Prince SabinaMahaboobkhan Rasool
Dec 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen E MalawistaPaul H Naccache
Jun 10, 2010·Journal of Periodontology·Vassilios PanisPetros D Damoulis
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Ming JinXiao-Feng Yang
Jun 21, 2011·La Presse médicale·Hang-Korng Ea
Dec 3, 2013·Annals of the Rheumatic Diseases·Nishant Dwivedi, Marko Radic
Apr 29, 2010·Current Rheumatology Reports·Fabio Martinon
Jan 25, 2013·Seminars in Immunopathology·Ioannis MitroulisKonstantinos Ritis
Jun 14, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Leila BenmoussaLoredana Radoï
Jan 3, 2015·The American Journal of Medicine·Anastasia SlobodnickSvetlana Krasnokutsky
Jul 26, 2013·American Journal of Therapeutics·Dur-Zong HsuMing-Yie Liu
Nov 18, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Payel SilBalázs Rada
Dec 21, 2016·European Journal of Immunology·Izabela GalvãoMauro M Teixeira
Mar 25, 2016·Clinical & Experimental Ophthalmology·Jack AoRobert J Casson
Sep 30, 2017·Nature Reviews. Rheumatology·Alexander K So, Fabio Martinon
Dec 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Payel SilBalázs Rada
Jan 11, 2012·Nature Reviews. Rheumatology·Fiona M McQueenNicola Dalbeth
Dec 29, 2019·British Journal of Pharmacology·Chengyu YinBoyi Liu
Apr 22, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hao WangElizabeth A Eklund
May 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lan PangBalázs Rada
Jun 23, 2018·Nature Reviews. Rheumatology·Falko ApelElaine F Kenny
Sep 5, 2018·Frontiers in Immunology·Maria J Fernandes, Paul H Naccache
May 28, 2017·Journal of Leukocyte Biology·Louis-Simon RousseauMaria Fernandes
Mar 17, 2018·Rheumatology·Tristan Pascart, Frédéric Lioté
Oct 9, 2019·International Journal of Molecular Sciences·Yu WangTing Yang
Mar 28, 2019·Frontiers in Pharmacology·Ana C RossaneisWaldiceu A Verri
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Rongmei YaoXiaolan Cui
Sep 2, 2017·Apoptosis : an International Journal on Programmed Cell Death·Monika SachetRudolf Oehler
Jan 30, 2021·Current Rheumatology Reports·Mehul P Jariwala, Ronald M Laxer
Mar 4, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yan-Nan LiuKe-Xuan Liu

❮ Previous
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