PMID: 9535656May 2, 1998Paper

Crystal structure and evolution of a transfer RNA splicing enzyme

Science
H LiJ Abelson

Abstract

The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschii was determined to a resolution of 2.3 angstroms. The structure indicates that the cleavage reaction is similar to that of ribonuclease A and the arrangement of the active sites is conserved between the archaeal and eucaryal enzymes. These results suggest an evolutionary pathway for splice site recognition.

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Citations

Dec 1, 1999·The Journal of Experimental Zoology·T H Waterman
Mar 20, 2012·Cellular and Molecular Life Sciences : CMLS·Johannes PopowJavier Martinez
Oct 15, 2009·Journal of Molecular Evolution·Junichi SugaharaAkio Kanai
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May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alissa M Anderson, Jonathan P Staley
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Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lennart RandauDieter Söll

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