Crystal structure and Hirshfeld surface analysis of (Z )-4-(4-hy-droxy-benzyl-idene)-3-methyl-isoxazol-5(4H )-one

Acta Crystallographica. Section E, Crystallographic Communications
Wissem ZemamoucheAbdelmadjid Debache

Abstract

The title compound, C11H9NO3, contains an isoxazole and a hy-droxy-benzyl-idene ring, which are inclined to each another by 3.18 (8)°. There is an intra-molecular C-H⋯O contact forming an S(7) ring. In the crystal, mol-ecules stack head-to-tail in columns along the b-axis direction, linked by offset π-π inter-actions [inter-centroid distances of 3.676 (1) and 3.723 (1) Å]. The columns are linked by O-H⋯O and O-H⋯N hydrogen bonds, forming layers parallel to the ab plane. The layers are linked by C-H⋯O hydrogen bonds, forming a supra-molecular three-dimensional framework. An analysis of the Hirshfeld surfaces points to the importance of the O-H⋯O and O-H⋯N hydrogen bonding in the packing mechanism of the crystal structure.

References

Jan 26, 2008·Chemical Communications : Chem Comm·Joshua J McKinnonMark A Spackman
Jan 17, 2009·Bioorganic & Medicinal Chemistry Letters·Yoon-Suk LeeByeang Hyean Kim
Jan 28, 2009·Acta Crystallographica. Section D, Biological Crystallography·Anthony L Spek
Dec 22, 2009·Bioorganic & Medicinal Chemistry Letters·Jialin MaoScott G Franzblau
Jul 20, 2010·European Journal of Medicinal Chemistry·Paola ContiCarlo De Micheli
Aug 10, 2010·European Journal of Medicinal Chemistry·Chatchawan ChangtamApichart Suksamrarn
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Qingfang ChengLi Zhang
Jan 4, 2013·Acta Crystallographica. Section E, Structure Reports Online· ChandraM Mahendra
Jan 9, 2015·Acta Crystallographica. Section C, Structural Chemistry·George M Sheldrick
Apr 7, 2016·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Colin R GroomSuzanna C Ward

❮ Previous
Next ❯

Citations

May 4, 2021·Acta Crystallographica. Section E, Crystallographic Communications·Rima LaroumAbdelmadjid Debache
May 25, 2021·Acta Crystallographica. Section E, Crystallographic Communications·Assia BenouatasAli Boudjada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Crystallographica. Section E, Crystallographic Communications
Ahmed M Abu-DiefSantiago Garcia-Granda
Acta Crystallographica. Section E, Crystallographic Communications
Rajamani RajaA SubbiahPandi
Acta Crystallographica. Section E, Structure Reports Online
C S DileepM A Sridhar
Acta Crystallographica. Section E, Structure Reports Online
Li WangRui Xu
Acta Crystallographica. Section E, Crystallographic Communications
Khairi SuhudMohammad B Kassim
© 2022 Meta ULC. All rights reserved