Crystal structure of a yeast TFIIA/TBP/DNA complex

Nature
S TanTimothy J Richmond

Abstract

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

References

Nov 1, 1992·Molecular and Cellular Biology·D K LeeR G Roeder
Nov 1, 1992·Acta Crystallographica. Section A, Foundations of Crystallography·D E Tronrud
Nov 5, 1992·Nature·D B NikolovS K Burley
Feb 1, 1991·Molecular and Cellular Biology·W Z Li, F Sherman
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1990·Methods in Enzymology·F W StudierJ W Dubendorff
Aug 1, 1988·Journal of Biomolecular Structure & Dynamics·R Lavery, H Sklenar
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Jun 1, 1995·Current Opinion in Cell Biology·E Maldonado, D Reinberg
Sep 14, 1995·Nature·D B NikolovS K Burley
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·J DeJongR G Roeder
Jun 1, 1995·Genes & Development·B M ShykindP A Sharp
Apr 1, 1994·Current Opinion in Genetics & Development·R Hori, M Carey
Nov 1, 1993·Genes & Development·J DeJong, R G Roeder
Jan 1, 1993·Annual Review of Biochemistry·R C Conaway, J W Conaway
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D I ChasmanR D Kornberg
Oct 7, 1993·Nature·Y KimP B Sigler
May 1, 1993·Genes & Development·D T Auble, S Hahn
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H TangR H Ebright

❮ Previous
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Citations

Jan 1, 1997·Biopolymers·R E Dickerson, T K Chiu
Mar 29, 2001·Proteins·L A StargellK J Lumb
Oct 15, 2013·Trends in Biochemical Sciences·Sebastian Grünberg, Steven Hahn
Sep 16, 2003·Journal of Molecular Biology·Michael BleichenbacherTimothy J Richmond
Feb 19, 2002·Molecular and Cellular Endocrinology·Mei Yin Ho, David Murphy
May 10, 2000·Current Opinion in Cell Biology·S Buratowski
Apr 18, 2002·Current Opinion in Structural Biology·Stephen K Burley, Katsuhiko Kamada
Mar 31, 1998·Current Opinion in Structural Biology·S Tan, T J Richmond
Sep 2, 1999·Trends in Biochemical Sciences·J C DantonelL Tora
Jul 17, 1998·Current Opinion in Chemical Biology·J P Wery, R W Schevitz
Jul 17, 1998·Current Opinion in Chemical Biology·J M CoxA Schepartz
Sep 1, 1996·Nature Genetics·E V Schmidt
Apr 29, 2004·Nature Structural & Molecular Biology·Steven Hahn
Feb 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anthony A NuaraMark R Walter
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T LagrangeD Reinberg
Jan 16, 2008·The Journal of Biological Chemistry·Mourad Bendjennat, P Anthony Weil
Apr 27, 1999·Journal of Biomolecular Structure & Dynamics·N PastorH Weinstein
Jul 23, 2004·Molecular Biology of the Cell·Philippe Kieffer-KwonIrwin Davidson
Feb 17, 2000·The EMBO Journal·J XieM Meisterernst
Feb 28, 2002·Nucleic Acids Research·Zdenek MorávekBohdan Schneider
Oct 21, 2011·Nucleic Acids Research·Mohamed-Amin ChoukrallahIrwin Davidson
Jul 3, 2007·Molecular Plant-microbe Interactions : MPMI·Anjali S Iyer-Pascuzzi, Susan R McCouch
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·R H Ebright
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·K StruhlZ Moqtaderi
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·F T TsaiP B Sigler
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·D ReinbergL Zawel
Sep 28, 2013·Science·Kenji MurakamiRoger D Kornberg
Jul 13, 2006·Eukaryotic Cell·Susan M KraemerLaurie A Stargell
Dec 31, 2008·Molecular and Cellular Biology·Wensheng DengStefan G E Roberts

❮ Previous
Next ❯

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