PMID: 8464909Apr 1, 1993Paper

Crystal structure of CATGGCCATG and its implications for A-tract bending models

Proceedings of the National Academy of Sciences of the United States of America
D S GoodsellR E Dickerson

Abstract

The single-crystal x-ray analysis of orthorhombic CATGGCCATG has revealed a previously unrecognized mode of intrinsic bending in DNA. The decamer shows a smooth bend of 23 degrees over the central four base pairs, caused by preferential stacking interactions at guanine bases. The bend is produced by a roll of base pairs along their long axes, in a direction that compresses the wide major groove of the double helix. This major-groove-compressing bend at GGC, plus the abundant crystallographic evidence that runs of successive adenine bases (A-tracts) are straight and unbent, requires rethinking of the models most commonly invoked to explain A-tract bending. A decade of excellent experimental work involving gel migration experiments, cyclization kinetics, and nucleosome phasing has clearly established that introduction of short A-tracts into a general DNA sequence in synchrony with the natural repeat of the helix leads to bending. But it does not logically and inevitably follow that the actual bending is to be found within these introduced A-tracts or even at junctions with general-sequence B-DNA.

References

May 20, 1991·Journal of Molecular Biology·S S Zinkel, D M Crothers
Nov 20, 1989·Journal of Molecular Biology·U Heinemann, C Alings
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A D DiGabrieleT A Steitz
May 5, 1988·Journal of Molecular Biology·C R CalladineM J McCall
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M CollA Rich
May 22, 1986·Nature·P J Hagerman
Oct 20, 1986·Journal of Molecular Biology·S C SatchwellA A Travers
Jul 5, 1985·Journal of Molecular Biology·E WesthofD Moras
Dec 20, 1985·Journal of Molecular Biology·H R Drew, A A Travers
Apr 10, 1986·Nature·H S KooD M Crothers
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P J Hagerman
Jul 23, 1981·Nature·D Rhodes, A Klug
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·R E DickersonP Pjura
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R E DickersonP Pjura
Oct 23, 1980·Nature·R WingR E Dickerson

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Citations

Sep 25, 1999·Journal of Molecular Biology·T K ChiuR E Dickerson
Aug 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·R MatyásekM Bezdĕk
May 1, 1994·Biophysical Chemistry·U HeinemannM Hahn
Apr 23, 2003·Journal of Molecular Biology·Hatim T AllawiVictor I Lyamichev
Aug 2, 2002·Bioorganic & Medicinal Chemistry·Inger Kers, Peter B Dervan
Dec 1, 1996·Quarterly Reviews of Biophysics·B Hartmann, R Lavery
Jun 11, 2009·Quarterly Reviews of Biophysics·Tali E Haran, Udayan Mohanty
Jul 13, 2006·Journal of the American Chemical Society·Raymond M DossPeter B Dervan
Jul 5, 2011·The Journal of Physical Chemistry. a·Petrina R N Kamya, Heidi M Muchall
Feb 14, 1998·Nature Structural Biology·C L KielkopfD C Rees
Mar 11, 1998·Natural Product Reports·S Neidle, C M Nunn
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R E DickersonS Neidle
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J K StraussL J Maher
Jun 1, 1996·Journal of Biomolecular Structure & Dynamics·R Chandrasekaran, S Arnott
Sep 22, 2001·Journal of Biomolecular Structure & Dynamics·U DornbergerH Fritzsche
Oct 25, 1993·Nucleic Acids Research·S A FawthropJ Fisher
Sep 11, 1994·Nucleic Acids Research·P Carrera, F Azorín
Dec 11, 1994·Nucleic Acids Research·D S Goodsell, R E Dickerson
Jun 25, 1995·Nucleic Acids Research·M Suzuki, N Yagi
May 10, 2002·Nucleic Acids Research·Yoji Umezawa, Motohiro Nishio
Sep 18, 2002·Nucleic Acids Research·Ho-Leung Ng, Richard E Dickerson
Dec 20, 2002·Nucleic Acids Research·Péter VárnaiBrigitte Hartmann
Jul 19, 2005·Nucleic Acids Research·Michael Y TolstorukovVictor B Zhurkin
Aug 10, 2000·Analytical Biochemistry·J Wildeson, C J Murphy
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·W HanR E Harrington
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·H SugiyamaA H Wang
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·I BruknerP Chartrand
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·H L NgR E Dickerson
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong Guo, Thomas D Tullius
Nov 8, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Alexandra MyariViktor Brabec
Oct 16, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Philip Ball

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