Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.

The Journal of Biological Chemistry
C EickenJ C Sacchettini

Abstract

VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1993·Protein Engineering·G J Barton
Jul 23, 1998·Infection and Immunity·J R Zhang, S J Norris
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger, J Berendzen
Nov 24, 1999·Journal of Clinical Microbiology·M B LawrenzS J Norris
Sep 22, 2000·Emerging Infectious Diseases·A G Barbour, B I Restrepo
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J E Purser, S J Norris
Jan 15, 2001·The Journal of Biological Chemistry·C EickenJ C Sacchettini
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J OhnishiA M de Silva
Jul 14, 2001·The New England Journal of Medicine·A C Steere
Nov 22, 2001·Biochemical and Biophysical Research Communications·K JonesP Wittung-Stafshede
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

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Citations

Feb 3, 2005·Nature Reviews. Microbiology·Patricia A RosaPhilip E Stewart
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dirar HomouzPernilla Wittung-Stafshede
May 26, 2009·Acta Crystallographica. Section D, Biological Crystallography·Thomas C TerwilligerLi Wei Hung
Apr 19, 2013·Clinical and Vaccine Immunology : CVI·Angela M FlodenCatherine A Brissette
Apr 29, 2009·Infection and Immunity·Kit TillyPatricia A Rosa
May 23, 2003·Infection and Immunity·Timothy R CrotherMichael A Lovett
Feb 24, 2004·Infection and Immunity·Wolfram R ZückertAlan G Barbour
Nov 19, 2013·PLoS Pathogens·Christopher J GravesDustin Brisson
Apr 1, 2009·International Journal of Molecular Sciences·Antonios SamiotakisMargaret S Cheung
Dec 17, 2014·International Journal of Molecular Sciences·Irina M KuznetsovaVladimir N Uversky
Oct 9, 2007·FEBS Letters·Michael PerhamPernilla Wittung-Stafshede
Aug 28, 2009·Cellular Microbiology·Guy H PalmerSheila A Lukehart
Mar 8, 2011·Journal of Molecular Biology·C Nick PaceGerald R Grimsley
Jul 28, 2007·Trends in Parasitology·Joppe W R HoviusErol Fikrig
Aug 20, 2015·Computational and Structural Biotechnology Journal·Janet Foley
Sep 6, 2007·Molecular Microbiology·Styliani AntonaraJenifer Coburn
Apr 11, 2008·Molecular Microbiology·Justin D Radolf, Melissa J Caimano
Feb 14, 2006·Molecular Microbiology·Ryan J Schulze, Wolfram R Zückert
Jun 27, 2006·Molecular Microbiology·Steven J Norris
Jun 12, 2013·Molecular Microbiology·Wolfram R Zückert
Mar 4, 2010·Protein Science : a Publication of the Protein Society·C Nick PaceGerald R Grimsley
Mar 5, 2014·Protein Science : a Publication of the Protein Society·C Nick PaceGerald R Grimsley
Aug 22, 2014·Protein Science : a Publication of the Protein Society·Steven J RysavyValerie Daggett
Feb 25, 2010·Acta Crystallographica. Section D, Biological Crystallography·Thomas C Terwilliger
Feb 25, 2010·Acta Crystallographica. Section D, Biological Crystallography·Thomas C Terwilliger
Feb 25, 2010·Acta Crystallographica. Section D, Biological Crystallography·Thomas C Terwilliger
Sep 1, 2004·The Lancet Infectious Diseases·Sunit Kumar Singh, Hermann Josef Girschick
Apr 14, 2005·Journal of Molecular Biology·Marco Punta, Burkhard Rost
Jul 23, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Abhishek ChandraArmin Alaedini

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