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Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes

Biochemistry

Jun 12, 1990

Hae-Joon Kim, William N. Lipscomb

PMID: 2386784

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Abstract

O-[[(1R)-[[N-(Phenylmethoxycarbonyl)-L-alanyl]amino]ethyl] hydroxyphosphinyl]-L-3-phenyllacetate [ZAAP(O)F], an analogue of (benzyloxycarbonyl)-Ala-Ala-Phe or (benzyloxycarbonyl)-Ala-Ala-phenyllactate, binds to carboxypeptidase A with great affinity (Ki = 3 pM). Similar phosphonates hav...read more

Mentioned in this Paper

Complex (molecular entity)
Hyrex Brand of Dimenhydrinate
X-Ray Diffraction
Carbene
Analog
Genetic Linkage
Abufne
Crystallography, X-Ray
Protein Conformation
Carboxypeptidase A5
12
Paper Details
References
  • References30
  • Citations49
123
  • References30
  • Citations49
12345

Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes

Biochemistry

Jun 12, 1990

Hae-Joon Kim, William N. Lipscomb

PMID: 2386784

DOI:

Abstract

O-[[(1R)-[[N-(Phenylmethoxycarbonyl)-L-alanyl]amino]ethyl] hydroxyphosphinyl]-L-3-phenyllacetate [ZAAP(O)F], an analogue of (benzyloxycarbonyl)-Ala-Ala-Phe or (benzyloxycarbonyl)-Ala-Ala-phenyllactate, binds to carboxypeptidase A with great affinity (Ki = 3 pM). Similar phosphonates hav...read more

Mentioned in this Paper

Complex (molecular entity)
Hyrex Brand of Dimenhydrinate
X-Ray Diffraction
Carbene
Analog
12

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Paper Details
References
  • References30
  • Citations49
123
  • References30
  • Citations49
12345

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