Crystal structure of the ectodomain of human FcalphaRI

The Journal of Biological Chemistry
Yi DingZihe Rao

Abstract

Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.

References

Apr 1, 1992·Human Genetics·E J KremerC R Maliszewski
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Oct 15, 1990·The Biochemical Journal·M A Kerr
Dec 1, 1990·The Journal of Experimental Medicine·C R MaliszewskiL Shen
Nov 15, 1990·The Biochemical Journal·R L Mazengera, M A Kerr
Feb 1, 1995·Kidney International·J H Galla
Apr 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H KlunglandS Lien
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Jan 6, 1999·Cell·S C GarmanT S Jardetzky
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger, J Berendzen
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G A SnyderP D Sun
May 20, 1999·Nature Structural Biology·K F MaxwellP M Hogarth
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B D WinesP M Hogarth
Nov 22, 2001·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger
Aug 28, 2002·Biochemical Society Transactions·P Sondermann, V Oosthuizen
Dec 21, 2002·Immunological Reviews·Randall S DavisMax D Cooper
Jan 14, 2003·Annual Review of Immunology·Renato C Monteiro, Jan G J Van De Winkel
Mar 14, 2003·Journal of Molecular Biology·Andrew B HerrPamela J Bjorkman
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

❮ Previous
Next ❯

Citations

Mar 26, 2004·Nature Reviews. Immunology·Jenny M Woof, Dennis R Burton
Apr 10, 2010·Glycobiology·Jing XueWei Zhang
Nov 27, 2004·International Archives of Allergy and Immunology·Monika JasekPiotr Kuśnierczyk
Sep 2, 2008·Immunological Reviews·Alexander David Barrow, John Trowsdale
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Akira NakamuraToshiyuki Takai
Jul 30, 2003·Nature Structural Biology·Beth A Wurzburg, Theodore S Jardetzky
Jun 22, 2011·MAbs·Jantine E Bakema, Marjolein van Egmond
Jul 29, 2005·Immunological Reviews·Jenny M Woof, Jiri Mestecky
Oct 27, 2015·Immunological Reviews·Jose M M CaaveiroKouhei Tsumoto
Sep 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Monica T PosgaiAndrew B Herr
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurent Abi-RachedPeter Parham
Oct 16, 2004·The Journal of Biological Chemistry·H Craig MortonPer Brandtzaeg
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jantine E BakemaJeanette H W Leusen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.