Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution

Molecular Cell
Andrew P MayE Yvonne Jones

Abstract

The structure of the functional N-terminal domain from the extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose. This provides structural information for the siglec family of proteins. The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features, including an intra-beta sheet disulphide and a splitting of the standard beta strand G into two shorter strands. These novel features appear important in adapting the V-set fold for sialic acid-mediated recognition. Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template. The complex is representative of the functional recognition interaction with carbohydrate and as such provides detailed information for a heterotypic cell adhesion interaction.

References

Sep 1, 1992·The Journal of Experimental Medicine·T K van den BergG Kraal
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D TyrrellD Asa
Aug 2, 1990·Nature·T A Springer
Jan 17, 1991·Nature·T A Springer, L A Lasky
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1990·Annual Review of Biochemistry·M Takeichi
Jul 1, 1990·Acta Crystallographica. Section A, Foundations of Crystallography·A T BrüngerJ W Erickson
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
Jan 1, 1981·Advances in Protein Chemistry·J S Richardson
Feb 1, 1994·Current Opinion in Immunology·R P McEver
Feb 1, 1995·The Journal of Clinical Investigation·P R CrockerS Kelm
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Sep 5, 1993·Journal of Molecular Biology·L Holm, C Sander
Apr 19, 1996·The Journal of Biological Chemistry·M VinsonP R Crocker
Mar 29, 1996·The Journal of Biological Chemistry·O BlanckK Drickamer
Jan 1, 1996·Annual Review of Biochemistry·W I Weis, K Drickamer
Jan 10, 1997·The Journal of Biological Chemistry·B E CollinsR L Schnaar
Mar 14, 1998·Glycobiology·P R CrockerA Varki
Nov 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·E A Merritt, M E Murphy
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

❮ Previous
Next ❯

Citations

Mar 28, 2012·Seminars in Immunopathology·Mariliis Klaas, Paul R Crocker
Jun 16, 2005·Current Opinion in Pharmacology·Paul R Crocker
Aug 28, 2001·Biochimie·A Varki
Dec 1, 2001·Progress in Neurobiology·S D SkaperF S Walsh
Sep 12, 2002·Biochimica Et Biophysica Acta·Remy Loris
Sep 12, 2002·Biochimica Et Biophysica Acta·Takashi Angata, Els Brinkman-Van der Linden
Dec 5, 2002·Current Opinion in Structural Biology·Paul R Crocker
Oct 6, 1999·Current Opinion in Structural Biology·J M Rini, Y D Lobsanov
Dec 23, 1999·Current Opinion in Structural Biology·M Vijayan, N Chandra
Jun 20, 2002·Journal of Biotechnology·Claus W von der LiethThisbe K Lindhorst
May 30, 2001·Trends in Immunology·P R Crocker, A Varki
Jul 25, 2009·Nature Reviews. Drug Discovery·Beat Ernst, John L Magnani
Mar 24, 2007·Nature Reviews. Immunology·Paul R CrockerAjit Varki
May 28, 2013·Nature Structural & Molecular Biology·Marie PanceraPeter D Kwong
Jun 20, 2001·Immunology·P R Crocker, A Varki
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·M Gordon JoycePeter D Sun
Dec 15, 2012·Journal of Carbohydrate Chemistry·Seok-Ho YuJennifer J Kohler
Nov 17, 2005·Bioinformatics·Eunhee KohHyun-Soo Cho
Dec 17, 2010·Protein Engineering, Design & Selection : PEDS·D BannisterR Minter
Aug 6, 2005·Transplantation·Christopher BurlakMichael A Rees
Jul 16, 2004·Journal of Virology·Peter L Delputte, Hans J Nauwynck
Dec 20, 2013·International Journal of Molecular Sciences·Yibo JiangShujun Zhang
Jul 1, 2014·Nature Communications·Stéphane MesnageMichael P Williamson
Nov 30, 2000·Biochemical and Biophysical Research Communications·G FoussiasE P Diamandis
Jun 21, 2001·Biochemical and Biophysical Research Communications·G FoussiasE P Diamandis
Aug 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takashi AngataAjit Varki

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