PMID: 9546398Apr 18, 1998Paper

Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT

Cell
L DitzelS Steinbacher

Abstract

We have determined to 2.6 A resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog of the eukaryotic chaperonin CCT/TRiC shows an (alphabeta)4(alphabeta)4 subunit assembly. Domain folds are homologous to GroEL but form a novel type of inter-ring contact. The domain arrangement resembles the GroEL-GroES cis-ring. Parts of the apical domains form a lid creating a closed conformation. The lid substitutes for a GroES-like cochaperonin that is absent in the CCT/TRiC system. The central cavity has a polar surface implicated in protein folding. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.

References

Jul 16, 1992·Nature·M B YaffeH Sternlicht
Nov 4, 1991·FEBS Letters·T E Gray, A R Fersht
Sep 6, 1990·Nature·W KabschK C Holmes
May 5, 1973·Journal of Molecular Biology·C P GeorgopoulosA D Kaiser
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K TillyC Georgopoulos
Sep 1, 1994·Protein Science : a Publication of the Protein Society·A GuagliardiM Rossi
Feb 1, 1995·European Journal of Biochemistry·T WaldmannW Baumeister
Mar 21, 1994·FEBS Letters·S MarcoW Baumeister
May 30, 1994·FEBS Letters·O LlorcaJ M Valpuesta
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H SternlichtM B Yaffe
Jan 1, 1993·Protein Engineering·G J Barton
Feb 1, 1996·Nature Structural Biology·D C BoisvertP B Sigler
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y W XuJ Cherfils

❮ Previous
Next ❯

Citations

Nov 13, 2004·Extremophiles : Life Under Extreme Conditions·Mina OkochiMasafumi Yohda
May 11, 2006·Extremophiles : Life Under Extreme Conditions·Takao YoshidaMasafumi Yohda
Jun 14, 2006·Extremophiles : Life Under Extreme Conditions·Sandra PucciarelliRonald Melki
Apr 1, 2009·Extremophiles : Life Under Extreme Conditions·Kristina BebloPetra Rettberg
Nov 26, 2008·Plant Molecular Biology·Celeste WeissAbdussalam Azem
Apr 6, 2005·Journal of Molecular Biology·Maria Giulia Bigotti, Anthony R Clarke
Sep 29, 2001·FEBS Letters·A R Kusmierczyk, J Martin
Aug 30, 2001·Trends in Genetics : TIG·A M Slavotinek, L G Biesecker
Apr 18, 2002·Current Opinion in Structural Biology·Xiaodong ZhangPaul S Freemont
Jan 23, 1999·Current Opinion in Structural Biology·R Jaenicke, G Böhm
May 26, 1999·Current Biology : CB·R J Ellis
Dec 7, 2002·Trends in Biochemical Sciences·Helen R Saibil, Neil A Ranson
Jul 20, 2000·Micron : the International Research and Review Journal for Microscopy·J L CarrascosaJ M Valpuesta
Oct 23, 1998·Nature Structural Biology·M NitschW Baumeister
Jan 22, 2010·Nature·Junjie ZhangWah Chiu
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Jason C YoungF Ulrich Hartl
Sep 13, 2013·Nature Reviews. Molecular Cell Biology·Helen Saibil
Mar 20, 2004·Nature Reviews. Microbiology·Pongpan LaksanalamaiFrank T Robb
May 20, 1998·Nature Structural Biology·A L Horwich, H R Saibil
Jun 10, 2008·Nature Structural & Molecular Biology·Christopher R BoothJudith Frydman
Dec 15, 2010·Nature Structural & Molecular Biology·Inés G MuñozGuillermo Montoya
Apr 27, 2007·Nature Structural & Molecular Biology·Stefanie ReissmannJudith Frydman
Oct 12, 2004·Nature Structural & Molecular Biology·B Trevor SewellHelen R Saibil
Feb 8, 2005·Nature Structural & Molecular Biology·Dalia Rivenzon-SegalAmnon Horovitz
Nov 16, 2006·European Journal of Human Genetics : EJHG·Dominic R A WhiteEamonn R Maher
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Seongjin SeoVal C Sheffield
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yao CongWah Chiu
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Brett J BakerJillian F Banfield
Nov 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen M Techtmann, Frank T Robb
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nir KalismanMichael Levitt
Jul 23, 2009·Protein Engineering, Design & Selection : PEDS·Timothy A WhiteheadDouglas S Clark

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.