PMID: 12763767May 24, 2003Paper

Crystal structures of Ca2+-ATPase in various physiological states

Annals of the New York Academy of Sciences
Chikashi ToyoshimaYuji Sugita

Abstract

The structures of the Ca(2+)-ATPase (SERCA1a) in different physiological states were determined by X-ray crystallography. Detailed comparison of the structures in the Ca(2+)-bound form and unbound (but thapsigargin bound) form reveals that very large rearrangements of the transmembrane helices take place accompanying Ca(2+) dissociation and binding and that they are mechanically linked with equally large movements of the cytoplasmic domains. The meaning of the rearrangement of the transmembrane helices becomes apparent by homology modeling of the Na(+)K(+)-ATPase.

References

Jun 8, 2001·The Biochemical Journal·A G Lee, J M East
Aug 9, 2002·Nature·Chikashi Toyoshima, Hiromi Nomura
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haruo Ogawa, Chikashi Toyoshima

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Citations

Oct 12, 2007·Cellular and Molecular Life Sciences : CMLS·J M ShinG Sachs
Jun 10, 2008·Pflügers Archiv : European journal of physiology·Jai Moo ShinGeorge Sachs
Apr 29, 2006·Digestive Diseases and Sciences·Jai Moo Shin, George Sachs
Sep 8, 2010·Current Gastroenterology Reports·Sascha Kopic, John P Geibel
Nov 10, 2009·Nature Structural & Molecular Biology·Alessandra PicolloAlessio Accardi
Mar 9, 2010·Plant & Cell Physiology·Keiichi Mochida, Kazuo Shinozaki
Aug 1, 2007·Journal of Clinical Gastroenterology·Michael J Caplan
Jun 30, 2012·Science Translational Medicine·Samuel R DenmeadeJohn T Isaacs
Nov 4, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mathias LübbenMarc Solioz
Dec 8, 2004·Developmental Biology·Michelle R GleasonGail Mandel
Jul 7, 2007·Biophysical Journal·Andreas FibichHans-Jürgen Apell
Jun 23, 2004·The Journal of Biological Chemistry·Melissa LaugheryJack H Kaplan
Sep 24, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Marc SoliozStefano Mancini
Feb 16, 2006·Muscle & Nerve·Ann E Rossi, Robert T Dirksen
Nov 6, 2009·American Journal of Physiology. Cell Physiology·Sascha KopicJohn P Geibel
Nov 2, 2019·Physiological Reviews·Amy C EngevikJames R Goldenring
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
Sep 21, 2007·The Journal of Biological Chemistry·Rosemarie ScanzanoRhoda Blostein
Jan 19, 2021·Archives of Biochemistry and Biophysics·Alfonso OlivaJosé A Teruel
Feb 8, 2020·Journal of Medicinal Chemistry·Lucie PeterkováSilvie Rimpelová
Oct 23, 2004·Biochemical Pharmacology·Jai Moo Shin, George Sachs
Aug 23, 2005·Brain Research. Brain Research Reviews·Ana M Mata, M Rosario Sepúlveda
Jul 26, 2005·Biophysical Journal·Christine Peinelt, Hans-Jürgen Apell
Jan 31, 2014·Chemical Reviews·Toshio AndoSimon Scheuring
Apr 10, 2019·The Journal of Organic Chemistry·Youssouf SanogoGeoffroy Sorin
Apr 29, 2014·Biochemistry·Bojana Damnjanovic, Hans-Jürgen Apell
Nov 17, 2007·Biochimica Et Biophysica Acta·Gianluca BartolommeiRolando Guidelli
Oct 19, 2011·Biophysical Journal·Andreas Fibich, Hans-Jürgen Apell

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