Crystalline Cyclophane-Protein Cage Frameworks

ACS Nano
Ngong Kodiah BeyehMauri A Kostiainen

Abstract

Cyclophanes are macrocyclic supramolecular hosts famous for their ability to bind atomic or molecular guests via noncovalent interactions within their well-defined cavities. In a similar way, porous crystalline networks, such as metal-organic frameworks, can create microenvironments that enable controlled guest binding in the solid state. Both types of materials often consist of synthetic components, and they have been developed within separate research fields. Moreover, the use of biomolecules as their structural units has remained elusive. Here, we have synthesized a library of organic cyclophanes and studied their electrostatic self-assembly with biological metal-binding protein cages (ferritins) into ordered structures. We show that cationic pillar[5]arenes and ferritin cages form biohybrid cocrystals with an open protein network structure. Our cyclophane-protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. Such host-guest materials are interesting for porous material applications, including water remediation and heterogeneous catalysis.

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Citations

Aug 9, 2019·Advanced Materials·Eduardo Anaya-PlazaMauri A Kostiainen
Nov 30, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Luke F Hartje, Christopher D Snow
Aug 16, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Antti KorpiMauri Kostiainen
Dec 29, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kwaku TwumNgong Kodiah Beyeh
Jun 12, 2021·Chemical Communications : Chem Comm·Dejun ZhangDerong Cao
Jul 20, 2021·Accounts of Chemical Research·Zewen ZhangYi Cui
Aug 19, 2021·Chemical Reviews·Jie ZhuF Akif Tezcan
Sep 7, 2019·ACS Nano·Sylvain EngilbergePeter B Crowley
Jan 20, 2022·Chemistry : a European Journal·Ahmed ShaukatMauri A Kostiainen

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Methods Mentioned

BETA
dynamic light scattering
X-ray
transmission electron microscopy
optical microscopy

Software Mentioned

Zetasizer
Gatan
GROMACS
Vitrobot
AA
MD

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