Crystalline plasma cell inclusions in helicobacter-associated gastritis

Journal of Clinical Pathology
C J R Stewart, D V Spagnolo

Abstract

Crystalline cytoplasmic inclusions are well documented in B cell lymphomas but have rarely been described in reactive plasmacytic infiltrates. Three cases of Lelicobacter-associated gastritis are described in which plasma cells focally contained rhomboid and needle-shaped crystalline inclusions. Crystalline inclusions were identified in the gastric biopsy specimens from three patients undergoing routine upper gastrointestinal endoscopy. The cells were characterised immunohistochemically using the following antisera: cytokeratin, leucocyte common antigen, desmin, CD20, CD68, CD79a, CD138, immunoglobulin (Ig)G, IgA and IgM heavy chains, and kappa and lambda Ig light chains. Clinical follow-up data were obtained. All biopsies showed a Lelicobacter-associated active chronic gastritis. Variable numbers of plasma cells with intracytoplasmic crystalline inclusions in the superficial lamina propria were seen. The crystals were not stained with any of the antisera tested, but the cells containing the crystals expressed CD79a and CD138 and, in the two assessable cases, showed IgA and lambda light chain immunoreactivity. The more numerous morphologically normal plasma cells in each patient were polytypic, and there were no histological fe...Continue Reading

References

Jan 1, 1984·Journal of Clinical Pathology·O PetersB Van Camp
Apr 1, 1994·Archives of Dermatology·R E JenkinsE Wilson-Jones
Aug 26, 1998·Human Pathology·R M Genta
Nov 28, 2002·Human Pathology·Ryuichi WadaSoroku Yagihashi
Jul 24, 2004·Archives of Pathology & Laboratory Medicine·Andreas ErbersdoblerGuntram Lock
Mar 4, 2005·Virchows Archiv : an International Journal of Pathology·Arzu EnsariRamazan Idilman

❮ Previous
Next ❯

Citations

Mar 21, 2012·Head and Neck Pathology·Snjezana DoganWilhelmina P Cruz-Vetrano
Dec 1, 2009·Journal of Medical Case Reports·Joanne VerheijLawrence Rozendaal
Mar 31, 2011·World Journal of Gastroenterology : WJG·Alessandro Del GobboSolange Romagnoli
Jul 9, 2014·Clinics and Research in Hepatology and Gastroenterology·Hejun ZhangRongli Cui
Jun 8, 2012·Pathology, Research and Practice·Alberto Paniz MondolfiNeil Theise
Dec 17, 2015·Diagnostic Pathology·You La JeonSang Ho Lee
Dec 25, 2008·Pathology, Research and Practice·Renáta LászlóLászló Pajor
Mar 31, 2007·Pathology, Research and Practice·Stefano PizzolittoGiovanni Falconieri
May 11, 2007·Veterinary Pathology·B ZimmermanL J Rush
Oct 15, 2011·International Journal of Surgical Pathology·John D Coyne, Bahram Azadeh
Jun 9, 2017·Journal of Pathology and Translational Medicine·Mee Joo
Oct 11, 2007·Helicobacter·Mario Milco D'Elios, Leif P Andersen
May 22, 2020·Journal of Pathology and Translational Medicine·Mee Joo, Nam-Hoon Kim
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor J TorresTimothy L Cover
Jul 31, 2021·Veterinary Clinical Pathology·Gary K C LeeRobert Darren Wood

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
H H ToppozadaE F El-Ghazzawi
International Journal of Surgical Pathology
Ricardo Drut, Alejandro B Olenchuk
© 2021 Meta ULC. All rights reserved