PMID: 6986900Jan 1, 1980Paper

Crystalline stromal dystrophy: histochemistry and ultrastructure of the cornea

The British Journal of Ophthalmology
R O Weller, F C Rodger

Abstract

A report of a woman in her fifties with Schnyder's crystalline stromal dystrophy is presented. There is no personal or family history of hypercholesterolaemia. A full thickness corneal disc was removed before grafting and examined by polarised light, histochemistry, and electron microscopy. Specific lipid histochemical methods showed deposits of cholesterol and cholesterol ester in the superficial stroma and in Bowman's membrane, but no triglyceride or free fatty acids were detected. Electron microscopy showed disruption of the superficial corneal stroma and Bowman's zone by cholesterol crystals and the presence of extracellular lamellated lipid droplets with a 4-4.5 nm periodicity. The epithelium, endothelium, and Descemet's membrane were virtually unaffected. The role of corneal grafting in crystalline stromal dystrophy is evaluated and the possible mechanisms of lipid accumulation in this disease are discussed.

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Citations

Jun 14, 2002·Progress in Retinal and Eye Research·Sheila Crispin
Jun 26, 1998·The British Journal of Ophthalmology·M YamadaY Mashima
Aug 15, 1987·American Journal of Ophthalmology·M M RodriguesR Willis
Nov 15, 1990·American Journal of Ophthalmology·M M RodriguesJ Blanchette-Mackie
Dec 1, 1993·Ophthalmology·H J IngrahamD D Donaldson
Dec 14, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Volkan HurmericJianhua Wang
Jul 7, 2016·Journal of Ophthalmology·Benjamin R LinAnthony J Aldave
Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P M GaynorH S Kruth
Dec 28, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Serena FragiottaK Bailey Freund
Jun 13, 2020·Nature Reviews. Disease Primers·Yu Qiang SohJodhbir S Mehta
Jul 1, 1991·Survey of Ophthalmology·B J BarchiesiP P Ellis

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