Crystallization and preliminary X-ray analysis of rat SHPS-1

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Aki NagataAtsushi Nakagawa

Abstract

SHPS-1, a receptor-type transmembrane protein, is abundantly expressed in neural and myeloid tissues. The most amino-terminal immunoglobulin-like domain of SHPS-1 plays an important role in a variety of cell functions by binding its ligand CD47. Interaction between SHPS-1 and CD47 is thought to be involved in negative regulation of phagocytosis. The ligand-binding domain of rat SHPS-1 was purified and crystallized using the vapour-diffusion method with the solution-stirring technique. Preliminary X-ray diffraction data were collected from SHPS-1 crystals to 2.8 A resolution and reduced to primitive hexagonal space group P622. Unit-cell parameters are a = b = 100.5, c = 101.3 A.

References

Feb 3, 1997·Biochemical and Biophysical Research Communications·T YamaoM Kasuga
Jun 17, 2000·Science·P A OldenborgF P Lindberg
Aug 31, 2000·The Journal of Biological Chemistry·X HanA Vignery
May 30, 2003·The EMBO Journal·Sei-Ichiro MotegiTakashi Matozaki

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Citations

Nov 30, 2007·Journal of Molecular Biology·Aki NakaishiAtsushi Nakagawa
Jun 4, 2013·International Journal of Molecular Sciences·Irene Russo KraussFilomena Sica

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