Crystallographic evidence for a CO/CO(2) tunnel gating mechanism in the bifunctional carbon monoxide dehydrogenase/acetyl coenzyme A synthase from Moorella thermoacetica

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Anne Volbeda, Juan C Fontecilla-Camps

Abstract

Acetyl coenzyme A synthase (ACS) acts in concert with carbon monoxide dehydrogenase (CODH) to catalyze the formation of acetyl-coenzyme A from CO(2)-derived CO and CH(3)(+) molecules. Recent crystal structures have shown that the three globular domains constituting the ACS subunit may be arranged in either a closed or an open conformation. A long hydrophobic tunnel network allows diffusion of CO between the CODH and the ACS active sites in the closed form, but it is blocked in the open form. On the other hand, the active site of ACS is only accessible for coenzyme A and the methyl donating protein in the open domain conformation. Although several metal compositions have been observed for this active site, present consensus is that it consists of a Ni-Ni-[Fe(4)S(4)] cluster. The observed conformational changes of ACS and the resulting different substrate accessibilities of the catalytic central nickel are reviewed here in the context of a putative CO(2)/CO tunnel gating mechanism.

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Citations

Apr 13, 2006·Journal of the American Chemical Society·Troy A StichThomas C Brunold
Jun 8, 2011·Metallomics : Integrated Biometal Science·Güneş BenderStephen W Ragsdale
Sep 5, 2015·Current Opinion in Structural Biology·Eva-Maria BurgerOliver Einsle
Feb 16, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Mériem MerrouchSébastien Dementin
Sep 26, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Tamar Kurzion-ZilbermannDan Meyerstein
Oct 20, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Anne Volbeda, Juan C Fontecilla-Camps
Feb 28, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xiangshi TanPaul A Lindahl
Mar 7, 2020·Biochimica Et Biophysica Acta. General Subjects·Nadia Elghobashi-MeinhardtMaria-Andrea Mroginski
Jun 9, 2005·Chemical Reviews·Israel ZilbermannDan Meyerstein
Apr 21, 2005·Journal of the American Chemical Society·Xiangshi TanPaul A Lindahl
Oct 4, 2013·The Journal of Physical Chemistry. a·Aleksandra ChmielowskaMaria Jaworska
May 30, 2013·Journal of the American Chemical Society·Po-hung WangJochen Blumberger
Jan 21, 2011·Inorganic Chemistry·Patricia AmaraJuan C Fontecilla-Camps
Apr 27, 2013·Chemical Reviews·Artur GoraJiri Damborsky
Feb 24, 2005·Journal of the American Chemical Society·Patricia AmaraMartin J Field

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