Crystals and crystallization in oil-in-water emulsions: implications for emulsion-based delivery systems

Advances in Colloid and Interface Science
David Julian McClements

Abstract

Many bioactive components intended for oral ingestion (pharmaceuticals and nutraceuticals) are hydrophobic molecules with low water-solubilities and high melting points, which poses considerable challenges to the formulation of oral delivery systems. Oil-in-water emulsions are often suitable vehicles for the encapsulation and delivery of this type of bioactive component. The bioactive component is usually dissolved in a carrier lipid phase by either dilution and/or heating prior to homogenization, and then the carrier lipid and water phases are homogenized to form an emulsion consisting of small oil droplets dispersed in water. The successful development of this kind of emulsion-based delivery system depends on a good understanding of the influence of crystals on the formation, stability, and properties of emulsions. This review article addresses the physicochemical phenomena associated with the encapsulation, retention, crystallization, release, and absorption of hydrophobic bioactive components within emulsions. This knowledge will be useful for the rational formulation of effective emulsion-based delivery systems for oral delivery of crystalline hydrophobic bioactive components in the food, health care, and pharmaceutical in...Continue Reading

References

Dec 4, 2001·Biochimica Et Biophysica Acta·V TyssandierP Borel
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A B HerholdH E King
Jun 14, 2002·Advances in Colloid and Interface Science·Daniel Quemada, Claudio Berli
Jun 24, 2003·Journal of Pharmaceutical Sciences·Heike BunjesKirsten Westesen
Feb 14, 2004·Advanced Drug Delivery Reviews·Barbara Rodríguez-SpongNaír Rodríguez-Hornedo
Apr 10, 2004·Advances in Colloid and Interface Science·Jean-Louis SalagerMarianna Rondón-González
Jul 22, 2004·International Journal of Pharmaceutics·K BouchemalH Fessi
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sergio FreitasBruno Gander
Feb 15, 2005·Drug Discovery Today·John S Delaney
May 25, 2005·The Journal of Chemical Physics·Daniel L Feltham, John Garside
Jul 19, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heike Bunjes, Michel H J Koch
Jul 29, 2005·Critical Reviews in Food Science and Nutrition·Shantha L Kosaraju
Nov 24, 2005·Journal of Agricultural and Food Chemistry·Saori OkudaEric A Decker
Dec 24, 2005·Critical Reviews in Food Science and Nutrition·T Matthew TaylorJochen Weiss
Jan 25, 2006·Critical Reviews in Food Science and Nutrition·I Higuera-CiaparaF M Goycoolea
Mar 2, 2006·Journal of Agricultural and Food Chemistry·Supratim GhoshJohn N Coupland
Mar 11, 2006·Critical Reviews in Food Science and Nutrition·John Flanagan, Harjinder Singh
Jul 4, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Colin W Pouton
Aug 15, 2006·Advances in Colloid and Interface Science·C HimawanA G F Stapley
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·Chi-Feng HungJia-You Fang
Oct 20, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anne des RieuxVéronique Préat
Jan 9, 2007·Colloids and Surfaces. B, Biointerfaces·Satoshi ArimaKiyotaka Sato
Jan 19, 2007·Advances in Colloid and Interface Science·Aviram Spernath, Abraham Aserin
Feb 24, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Heike BunjesWalter Richter
Mar 3, 2007·Nature Reviews. Drug Discovery·Christopher J H PorterWilliam N Charman
Mar 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luca MarcianiRobin C Spiller
Apr 21, 2007·Colloids and Surfaces. B, Biointerfaces·Hong YuanHang-Li Zhao
Jun 6, 2007·Journal of Colloid and Interface Science·S QuesteJ M Aubry
Jul 3, 2007·Advanced Drug Delivery Reviews·Filippos KesisoglouYunhui Wu
Sep 18, 2007·Regulatory Toxicology and Pharmacology : RTP·Werner I HagensAdriënne J A M Sips
Nov 13, 2007·Journal of Food Science·D J McClementsJ Weiss
Dec 28, 2007·Advanced Drug Delivery Reviews·Christopher J H PorterPanayiotis Constantinides
Feb 2, 2008·Journal of Agricultural and Food Chemistry·Caitlin S BoonEric A Decker
Apr 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas AntonPatrick Saulnier
Apr 25, 2008·Journal of Agricultural and Food Chemistry·Lucile BonnaireDavid Julian McClements
Jun 20, 2008·Journal of Colloid and Interface Science·Lennart LindforsUlf Olsson
Jun 26, 2008·Journal of Food Science·F Kong, R P Singh
Oct 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Medha D Joshi, Rainer H Müller
Oct 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Tim J WoosterPeerasak Sanguansri
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
Nov 26, 2008·Regulatory Toxicology and Pharmacology : RTP·Hans BouwmeesterAdriënne J A M Sips
Jan 1, 2009·Progress in Lipid Research·Harjinder SinghDavid Horne

❮ Previous
Next ❯

Citations

Jan 22, 2013·Journal of Agricultural and Food Chemistry·Ayse KaradagQingrong Huang
Jan 21, 2014·Ultrasonics Sonochemistry·Shabbar AbbasXiaoming Zhang
Nov 19, 2013·Advances in Colloid and Interface Science·M DouaireI T Norton
Oct 14, 2014·Drug Development and Industrial Pharmacy·M Michaelis, C S Leopold
Sep 6, 2012·Journal of Pharmaceutical Sciences·Zdravka MisicMartin Kuentz
Feb 3, 2015·Journal of Agricultural and Food Chemistry·Liqiang ZouDavid Julian McClements
Jun 15, 2013·Electrophoresis·Yung-Sheng LinHaw-Ming Huang
Mar 10, 2015·Critical Reviews in Food Science and Nutrition·Cheryl ChungDavid Julian McClements
May 16, 2015·Journal of Agricultural and Food Chemistry·Choongjin BanYoung Jin Choi
Apr 7, 2015·Journal of Agricultural and Food Chemistry·Gabriel Davidov-PardoDavid Julian McClements
May 15, 2013·Progress in Lipid Research·David Julian McClements
Jan 1, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Sai Sateesh SagiriKunal Pal
Dec 30, 2014·Journal of Agricultural and Food Chemistry·Yuwen TingQingrong Huang
Aug 1, 2016·The Journal of Chemical Physics·W J SmitH J Bakker
Dec 18, 2013·Annual Review of Food Science and Technology·Mingfei YaoDavid Julian McClements
Feb 10, 2017·Journal of Agricultural and Food Chemistry·Ying YangJinkai Zheng
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Mahesh KharatDavid Julian McClements
Mar 30, 2017·Food & Function·Rachel E KopecCatherine Caris-Veyrat
Dec 3, 2017·Applied Biochemistry and Biotechnology·Rodrigo A MancillaAlejandro Amoroso
Nov 8, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Mohamed E I BadawyAmany D Abd-Elnabi
Sep 19, 2017·Food & Function·W A Fahmi Wan MohamadM A Augustin
Jun 9, 2018·Critical Reviews in Food Science and Nutrition·Elham Assadpour, Seid Mahdi Jafari
Apr 16, 2019·Journal of Microencapsulation·Boontida MorakulVaraporn Buraphacheep Junyaprasert
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Aug 14, 2019·Molecular Nutrition & Food Research·Rachel E KopecPatrick Borel
Jul 1, 2017·Journal of Microencapsulation·Sudipta Chatterjee, Zaher M A Judeh
Apr 16, 2020·Physical Review. E·Samira AbediSiva A Vanapalli
Oct 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takashi KuroiwaAkihiko Kanazawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.