Cs₂CO₃-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Cheng DongLi-Wen Xu

Abstract

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones.

References

May 8, 1997·Chemical Reviews·G. K. Surya Prakash, Andrei K. Yudin
Mar 13, 2003·Chemical Reviews·Alexander D Dilman, Sema L Ioffe
Dec 9, 2004·Chemical Reviews·Jun-An Ma, Dominique Cahard
Sep 30, 2005·Journal of the American Chemical Society·Gregory T NottePeter J Steel
Sep 26, 2008·The Journal of Organic Chemistry·Jean NonnenmacherCharles Portella
Sep 3, 2009·Journal of the American Chemical Society·David A NagibDavid W C MacMillan
Apr 5, 2011·Chemical Reviews·Olesya A Tomashenko, Vladimir V Grushin
May 1, 2012·Bioorganic & Medicinal Chemistry Letters·Yosup RewJay P Powers

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Methods Mentioned

BETA
X-ray
column chromatography

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