PMID: 7540405Mar 1, 1995Paper

CSF-1 treatment promotes angiogenesis in the metaphysis of osteopetrotic (toothless, tl) rats

Bone
S AharinejadE Wiesbauer

Abstract

It has recently been shown that following treatment with colony-stimulating factor-1 (CSF-1) the osteopetrotic condition in toothless (tl) rats greatly improves and growth is accelerated. We have examined the effects of such treatment on the microvasculature of the distal femoral chondro-osseous junction, a site where bone growth in length is coordinated with angiogenesis. Vascular casts and ultrastructural analyses of this region showed that, compared to untreated normal rats, untreated mutants showed little bone growth or angiogenesis. When mutants were treated with CSF-1 angiogenesis was markedly accelerated. These data show a remarkable effect of this growth factor on angiogenesis in this osteopetrotic mutation. Whether this effect of CSF-1 on angiogenesis is direct or indirect is not known and indicates that its effects on the normal microvasculature deserve further study.

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Citations

Jun 18, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S C MarksS N Popoff
Oct 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Liesbeth Van WesenbeeckSandy C Marks
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