Jan 29, 2000

CSF 5-HIAA and nighttime activity in free-ranging primates

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
P T MehlmanJ D Higley

Abstract

Men with low CNS serotonin turnover, as measured by cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations, exhibit aberrant circadian activity patterns characterized by disrupted sleep rhythms and daytime hyperactivity. To assess whether similar patterns are found in nonhuman primates we examined the relationships between CSF 5-HIAA and nighttime activity in free-ranging monkeys. CSF samples were obtained from 16 adult male rhesus macaques living on a 475 acre, heavily forested sea island. Each subject was captured, fitted with a radio-telemetry motion-detector collar, and then released back into its group. A receiver placed near the sleeping trees of the study subjects recorded activity between 2100 hrs and 0600 hrs. Trained observers recorded behavioral data during the day. The animals followed a typical diurnal activity pattern, as they were active 74% of the sampled time during the day and 37% of the sampled time during the night. CSF 5-HIAA concentrations were inversely correlated with total duration of nighttime activity as well as mean duration of all active events. Nighttime activity was inversely correlated with daytime activity. CSF 3-methoxy-hydroxyphenylglycol (MHPG) concentrations were positive...Continue Reading

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Mentioned in this Paper

Homovanillic Acid
Nonhuman primate
Serotonin Measurement
Sleep, Slow-Wave
Darkness
Serotonin
Synaptic Transmission
Cerebrospinal Fluid
Cercopithecidae
Platyrrhini

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