PMID: 7011523Nov 1, 1980Paper

CSF electrophoresis in one thousand patients

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
G C Ebers, D W Paty

Abstract

Agarose and/or cellulose acetate electrophoresis was performed on the CSF of one thousand patients. In patients with clinically definite multiple sclerosis (MS) (N = 267) 92.8% had oligoclonal banding (O.B.). In patients with possible MS (N = 283) O.B. was present in 31.1%. In patients with other neurological diseases (N = 450) O.B. was present in 8% (N = 36). Nineteen non-MS patients with positive O.B. had serum bands or disorders known to be associated with local immune response. The remaining 17 patients had no explanation for the oligoclonal banding. In the majority of these MS had not been a diagnostic consideration. CSF electrophoresis is the single most reliable laboratory test in multiple sclerosis and deserves incorporation into the diagnostic criteria for the disease.

References

Jun 1, 1976·Neurology·A S RoseW W Tourtellotte
Aug 1, 1978·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D W PatyM E Bernardo
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Jan 1, 1980·Journal of Immunological Methods·G C EbersH Armstrong
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·O MEULEMANS

❮ Previous
Next ❯

Citations

Aug 17, 2006·Der Nervenarzt·H WiendlH-P Hartung
Aug 1, 1988·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D W Paty
Jan 1, 1984·Annals of the New York Academy of Sciences·W W TourtellotteP Shapshak
Feb 1, 1983·Annals of Neurology·L E Davis, L C McLaren
Jan 1, 1984·Annals of the New York Academy of Sciences·G C Ebers
Sep 1, 1982·Acta Neurologica Scandinavica·J CrippsG C Ebers
Feb 7, 2017·British Journal of Hospital Medicine·Adrian Ys LeeStephen Adelstein
Aug 1, 1982·Scandinavian Journal of Immunology·G C Ebers
Mar 1, 1993·Annals of Neurology·A D SadovnickT J Murray
Jan 12, 2007·The Neurologist·Dean M Wingerchuk
Apr 19, 2015·Current Opinion in Neurology·Ilana Katz Sand
May 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A J HudsonJ C Kaufmann
May 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G C Ebers, T E Feasby
May 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T E FeasbyA J Fox
Sep 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Maciej JuryńczykJacqueline Palace
Feb 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A CostantinoJ H Noseworthy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.