CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers

Schizophrenia Research
M H RapaportS M Paul

Abstract

It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1 alpha and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150) ng/ml (controls) for IL-1 alpha and 0.970 (0.038) ng/ml (patients) vs. 1.25 (0.086) ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1 alpha and IL-2 levels for all subjects (r = 0.50, n = 44, p = 0.0001).

References

Apr 1, 1991·Journal of Neuroimmunology·D MaimoneA T Reder
Nov 1, 1990·Archives of General Psychiatry·T E GoldbergD R Weinberger
Mar 22, 1990·The New England Journal of Medicine·R L SuddathD R Weinberger
May 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·M F CasanovaD R Weinberger
Oct 1, 1989·Archives of General Psychiatry·C G McAllisterS M Paul
Mar 1, 1989·Archives of General Psychiatry·M H RapaportS M Paul
Aug 1, 1989·Biological Psychiatry·R GanguliS H Belle
Jan 1, 1987·Annals of the New York Academy of Sciences·R GanguliU Ragu
Sep 1, 1987·Annals of Internal Medicine·K D DenicoffS A Rosenberg
Mar 1, 1994·The American Journal of Psychiatry·R E GurR C Gur
Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·M H RapaportS M Paul
May 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·R S el-MallakhR J Wyatt

❮ Previous
Next ❯

Citations

Jun 25, 2008·European Archives of Psychiatry and Clinical Neuroscience·Yuichiro WatanabeToshiyuki Someya
Dec 17, 2011·European Archives of Psychiatry and Clinical Neuroscience·Nenad VasicJohannes Brettschneider
May 7, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sinead M Gibney, Hemmo A Drexhage
Oct 18, 2000·European Journal of Pharmacology·C C Gispen-de Wied
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiang Yang ZhangYu Cun Shen
Jul 7, 2010·Psychiatry and Clinical Neurosciences·Yuichiro WatanabeHiroyuki Nawa
Nov 7, 1998·Brain Research·S ZalcmanD M Nance
Mar 5, 2003·Biological Psychiatry·Xiao-Fen WangMark Hyman Rapaport
Sep 18, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roksana Zakharyan, Anna Boyajyan
Jan 10, 2002·Brain, Behavior, and Immunity·M RothermundtT A Bayer
Jan 10, 2002·Brain, Behavior, and Immunity·M J SchwarzM Ackenheil
Jan 21, 2015·Schizophrenia Research·Hui-Mei AnXiang Yang Zhang
Jul 6, 2007·Expert Review of Neurotherapeutics·Xiaoduo FanDavid C Henderson
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David L GarverJennifer A Holcomb
Jul 6, 2007·Psychiatry and Clinical Neurosciences·Yuichiro WatanabeToshiyuki Someya
Sep 17, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·A Carlo AltamuraSerena Vismara
Apr 24, 2018·Psychiatry Research·Alireza MohammadiVahid Ghasem Amooeian
Nov 13, 2021·Postgraduate Medicine·Zarrin AnsariRajmohan Seetharaman

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.