CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Enrico FainardiOlavio R Baricordi

Abstract

Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting (RR) MS patients classified according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Sixty-four patients with other inflammatory neurological disorders (OIND) and 64 subjects with noninflammatory neurological disorders (NIND) served as controls. CSF concentrations were higher in RRMS and in OIND than in NIND patients for sHLA-I (P < 0.02), greater in RRMS than in OIND and in NIND for sHLA-G (P < 0.001 and P < 0.01, respectively) and lower in RRMS than in OIND and in NIND for sFas (P < 0.001 and P < 0.02, respectively). An increase in CSF levels was identified in MRI active RRMS for sHLA-I (P < 0.01) and in MRI stable RRMS for sHLA-G (P < 0.01), whereas CSF values of sFas were decreased in RRMS without Gd-enhancing lesions (P < 0.02). In MS patients with no evidence of MRI disease activity, a trend towards an inverse correlation was found between CSF concentrations of sHLA-G and sHLA-I and between CSF levels of sHLA-G and sFas. Our results indicate that enha...Continue Reading

References

Jan 1, 1992·Journal of Neuroimmunology·J C Alvarez-CermeñoP González-Porqué
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1997·Acta Neurologica Scandinavica·S BansilC Rohowsky-Kochan
Apr 4, 1998·Journal of Neuroimmunology·Emilio CiusaniAndrea Salmaggi
Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T SakaiM Osame
Nov 18, 2000·Acta Neurologica Scandinavica·C HeesenB G Schoser
Feb 27, 2001·International Immunology·A HoruzskoA L Mellor
Sep 28, 2001·Trends in Immunology·E D CarosellaN Rouas-Freiss
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M K Sharief
Jan 25, 2002·European Journal of Immunology·Beatrice FuzziOlavio R Baricordi
May 22, 2003·Acta Neurologica Scandinavica·M BilinskaE Gruszka
Sep 17, 2003·Tissue Antigens·J LeMaoultE D Carosella
Jan 24, 2004·Brain Research. Brain Research Reviews·Chulhee Choi, Etty N Benveniste
Jun 5, 2004·Clinical Neurology and Neurosurgery·Darija MahovicSanja Hajnsek
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Jun 30, 2005·Rheumatology International·Irena AdamashviliJohn C McDonald
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Solène Le RondNathalie Rouas-Freiss
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Apr 3, 2007·Human Immunology·Heinz Wiendl

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Citations

Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Eduardo A DonadiPhilippe Moreau
Jun 23, 2011·Journal of Neural Transmission·Trevor W StoneL Gail Darlington
Jun 6, 2013·Molecular and Cellular Biochemistry·Roberta RizzoTiziana Bellini
Apr 30, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabio MorandiVito Pistoia
Jun 27, 2012·Brain : a Journal of Neurology·Gurman KaurLars Fugger
Nov 17, 2010·Cellular and Molecular Life Sciences : CMLS·Enrico FainardiJosè Peña
Nov 19, 2010·Cellular and Molecular Life Sciences : CMLS·Yu-Hwa HuangHeinz Wiendl
May 1, 2011·Expert Opinion on Medical Diagnostics·John W Rose, Noel G Carlson
Jan 31, 2016·Human Immunology·Susann PankratzHeinz Wiendl
Aug 5, 2009·Human Immunology·Enrico FainardiOlavio Roberto Baricordi
Dec 12, 2012·Human Immunology·Roberta RizzoMarcello Govoni
Jul 28, 2012·Journal of the Neurological Sciences·Enrico TongiorgiGilberto Pizzolato
Dec 6, 2014·Frontiers in Immunology·Roberta RizzoEnrico Fainardi
Sep 11, 2007·Seminars in Cancer Biology·Vito PistoiaSoldano Ferrone
Jun 19, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Enrico FainardiUNKNOWN ERMES study group
Apr 17, 2018·Clinical and Experimental Immunology·P ContiniF Puppo
Sep 23, 2014·World Journal of Methodology·Daria BortolottiDario Di Luca
Oct 2, 2020·International Journal of Immunogenetics·Antonio Arnaiz-VillenaJose M Martin-Villa
Sep 15, 2020·Frontiers in Immunology·Maria LoustauJulien Caumartin

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