PMID: 6200411Jan 1, 1983

CSF monoamine metabolism in patients with tardive dyskinesia: effect of oxypertine and hydroxyzine pamoate

Folia Psychiatrica Et Neurologica Japonica
K AkiyamaS Otsuki


Cerebrospinal fluid (CSF) HVA, MHPG, 5-HIAA, cAMP and cGMP concentrations were measured in schizophrenic patients with tardive dyskinesia before and after a three-week administration of oxypertine (n = 4), hydroxyzine pamoate (n = 4) or placebo (n = 4). The oxypertine administration resulted in a reduction of the CSF HVA concentration and an elevation of the MHPG and cAMP concentrations, associated with a clinical improvement in tardive dyskinesia. The hydroxyzine administration reduced the CSF 5-HIAA concentration in all the patients and the CSF HVA concentration in two of four patients with a clinical improvement. A reduction in the CSF HVA concentration associated with possible therapeutic effects of oxypertine or hydroxyzine may suggest the normalization of a hyperdopaminergic state. Discussions were held that functional disorders of not only the dopaminergic system but the norepinephrinergic and serotoninergic systems may relate to the pathogenesis of tardive dyskinesia.


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Jul 1, 2008·General Hospital Psychiatry·Jesus Ramirez-BermudezCamilo Rios
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Related Concepts

Cyclic AMP, (R)-Isomer
Biogenic Amines
Clinical Trials
Dyskinesia, Medication-Induced
Cyclic GMP
Homovanillic Acid
Hydroxyindoleacetic Acid
Hydroxyzine Dihydrochloride
Methoxyhydroxyphenylglycol, (-)-Isomer

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