CSF neurogranin or tau distinguish typical and atypical Alzheimer disease

Annals of Clinical and Translational Neurology
Henrietta WellingtonJonathan Schott

Abstract

To assess whether high levels of cerebrospinal fluid neurogranin are found in atypical as well as typical Alzheimer's disease. Immunoassays were used to measure cerebrospinal fluid neurogranin in 114 participants including healthy controls (n = 27), biomarker-proven amnestic Alzheimer's disease (n = 68), and the atypical visual variant of Alzheimer's (n = 19) according to international criteria. CSF total-tau, Aβ42, and neurofilament light concentrations were investigated using commercially available assays. All affected individuals had T1-weighted volumetric MR images available for analysis of whole and regional brain volumes. Associations between neurogranin, brain volumes, total-tau, Aβ42, and neurofilament light were assessed. Median cerebrospinal fluid neurogranin concentrations were higher in typical and atypical Alzheimer's compared to controls (P < 0.001 and P = 0.005). Both neurogranin and total-tau concentrations, but not neurofilament light and Aβ42, were higher in typical Alzheimer's compared to atypical patients (P = 0.004 and P = 0.03). There were significant differences in the left hippocampus and right and left superior parietal lobules in atypical patients, which were larger (P = 0.03) and smaller (P = 0.001 an...Continue Reading

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Citations

Aug 9, 2019·Neurodegenerative Disease Management·Bonnie WongBradford C Dickerson
Apr 16, 2020·Annals of Clinical and Translational Neurology·Keith A JosephsJennifer L Whitwell
Jul 16, 2020·Brain : a Journal of Neurology·Katheryn A Q CousinsJeffrey S Phillips
Nov 14, 2019·Neural Regeneration Research·Anna Villar-PiqueFranc Llorens
Oct 9, 2020·Expert Review of Proteomics·Sonia MazzucchiFilippo Baldacci
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Feb 21, 2021·Lancet Neurology·Jonathan Graff-RadfordMelissa E Murray
Mar 16, 2021·Journal of Alzheimer's Disease : JAD·Heikki LukkarinenVille Leinonen
May 15, 2021·Frontiers in Aging Neuroscience·Yulan FanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Methods Mentioned

BETA
PCA
ELISA

Software Mentioned

Statistical Parametric Mapping ( SPM )
Matlab

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