CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD

Annals of Clinical and Translational Neurology
Natalia ErmannFranc Llorens

Abstract

Creutzfeldt-Jakob disease and Alzheimer's disease are characterized by the presence of elevated total-Tau cerebrospinal fluid concentrations while the presence of hyperphosphorylated Tau forms in the cerebrospinal fluid is rather a hallmark of Alzheimer's disease. Here we aimed to investigate potential contribution of nonphospho-Tau epitopes (non-P-Tau) in the discrimination between both diseases. Non-P-Tau cerebrospinal fluid concentration was highly increased in Creutzfeldt-Jakob disease (n = 57, 3683 ± 3599 pg/mL) compared to Alzheimer's disease (n = 41, 148 ± 219 pg/mL) and neurological controls (n = 56, 62 ± 40 pg/mL), and significantly improved the proportion of correctly classified patients (99%) compared to that achieved by total-Tau (90%), P-Tau (62%) and 14-3-3 (91%).

References

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Aug 9, 2011·Expert Review of Proteomics·Piotr Lewczuk, Johannes Kornhuber
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Piotr LewczukJohannes Kornhuber

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Citations

Nov 10, 2018·Journal of Alzheimer's Disease : JAD·Lilian Calderón-GarcidueñasIngolf Lachmann
Jul 12, 2019·Frontiers in Neuroscience·Camille PernègreNicole Leclerc
May 10, 2020·Pharmacological Reports : PR·Piotr LewczukJohannes Kornhuber
May 6, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·S LehmannUNKNOWN ePLM Group
May 1, 2021·Viruses·Mark P Figgie, Brian S Appleby

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BETA
ELISA

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