PMID: 9531015Apr 8, 1998Paper

CSF, plasma viral load and HIV associated dementia

Journal of Neurovirology
Kevin RobertsonC Hall

Abstract

Plasma viral burden has proven valuable in predicting the future course of systemic HIV related disease and the response to treatment. It is not known whether plasma or cerebrospinal fluid (CSF) viral burden can be used to predict onset of or response to treatment of nervous system disease. We propose a model of viral load mediated neurotoxicity underlying peripheral and central HIV associated neurological disease. The objective of this preliminary study was to assess the relationship of HIV associated neurological disease to quantitative viral load in plasma and CSF. 47 subjects (HIV- = 10, HIV+ = 37) participated in the study. Plasma and CSF samples were collected within a 3 h window. RT-PCR (Roche Amplicor Monitor) was utilized to assess HIV-1 RNA viral load in both plasma and cell free (centrifuged) CSF. Subjects underwent concurrent comprehensive neurological and neuropsychological evaluations. In general, systemic viral load, as measured in plasma, was greater than that found in cell free CSF. Cell free CSF HIV RNA viral load was significantly correlated with neurological dysfunction, whereas plasma viral load was not. The sole subject with an elevated CSF viral load (> 5 Log 10), had HIV associated dementia (HAD) on clin...Continue Reading

Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph P SteinerAvindra Nath
May 11, 2002·Current Psychiatry Reports·Francisco Fernandez
Aug 21, 2010·Immunologic Research·K Grovit-Ferbas, M E Harris-White
Dec 3, 1999·Journal of the Neurological Sciences·L AnderssonM Gisslén
Mar 29, 2008·Journal of Neurovirology·Kevin RobertsonUNKNOWN Second Assessment of NeuroAIDS in Africa Conference Participants
Oct 29, 2000·AIDS Research and Human Retroviruses·A V AlbrightF González-Scarano
Oct 22, 2011·Cerebral Cortex·Kalpana J KallianpurCecilia Shikuma
Jan 1, 2005·AIDS·Bruce ShiramizuVictor Valcour
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Serena Spudich, Francisco González-Scarano
Oct 19, 2004·Clinical Microbiology Reviews·Roberta L Debiasi, Kenneth L Tyler
Apr 11, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Bruce ShiramizuVictor Valcour
May 13, 2010·Virology Journal·Amber T WashingtonAshok Aiyar
Aug 15, 2012·Seminars in Pediatric Neurology·Ayesha Mirza, Mobeen H Rathore
Mar 10, 2007·Brain, Behavior, and Immunity·Kathy L KopniskyYu Woody Lin
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kevin R RobertsonColin D Hall
Mar 12, 2005·Cell Death and Differentiation·M P MattsonA Nath
Sep 10, 2014·Current Opinion in HIV and AIDS·Lachlan R GrayMelissa J Churchill
Jul 31, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M GisslénL Hagberg
Feb 27, 2018·Practical Neurology·Emily HobbsDavid Lawrence
Sep 15, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Paulo Pereira ChristoJose António Livramento
Apr 4, 2000·Journal of Clinical Microbiology·R N ShepardS A Fiscus
Aug 26, 2021·Retrovirology·E A Nickoloff-BybelP J Gaskill

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.