PMID: 591981Dec 1, 1977

CSF studies on the relationship between dopamine and 5-hydroxytryptamine in Parkinsonism and other movement disorders

Journal of Neurology, Neurosurgery, and Psychiatry
D DavidsonH Wilson

Abstract

In Parkinson's disease, the concentration of homovanillic acid (HVA) was reduced in lumbar CSF from patients with idiopathic Parkinsonism (n = 54, P less than 0.05) and post-encephalitic Parkinsonism (n = 19, P less than 0.01). The reduction in the concentrations of 5-hydroxyindolylacetic acid (5-HIAA) was not significant, and there was no alteration in the levels of 4-hydroxy-3-methoxyphenylethylene glycol (MHPG). Treatment with L-dopa increased the concentration of HVA in the CSF (P less than 0.05) but had no effect on the levels of 5-HIAA and MHPG. Carbidopa given in combinations with L-dopa produced similar CSF concentrations of dopa as did L-dopa alone but caused less than half the rise in HVA. Fourteen patients who became functionally independent on treatment with L-dopa had higher 5-HIAA levels than 23 patients who showed no such improvement (P less than 0.001), suggesting that intact 5-hydroxyltryptamine neurones may be important in the therapeutic response to L-dopa. In a variety of movement disorders, the levels of HVA, 5-HIAA, and MHPG were not significantly different from age-matched controls. Treatment with tetrabenazine did not significantly alter the metabolite levels in patients in whom it produced either improv...Continue Reading

References

Aug 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·D DavidsonC M Yates
Nov 14, 1970·Lancet·T N Chase
Jul 17, 1971·Lancet·J P LakkeH M van Praag
Dec 4, 1971·Lancet·T N Chase, L K Ng
Apr 1, 1970·The Journal of Pharmacy and Pharmacology·L ButcherK Fuxe
May 1, 1972·Neurology·T N ChaseA M Watanabe
Jan 1, 1973·The American Journal of Psychiatry·R M PostE K Gordon
May 1, 1973·Journal of the Neurological Sciences·J GumpertG Curzon
Oct 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·W J Weiner, H L Klawans
Jan 1, 1974·European Journal of Clinical Pharmacology·A K GranerusA Svanborg
Dec 1, 1972·Archives of Neurology·T N Chase, L K Ng
Jan 1, 1970·Experientia·M H van Woert, M B Bowers
Dec 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·I A PullarF J Gillingham
Jun 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·R B Godwin-Austen

Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·N PomaraD Deptula
Jan 1, 1994·Journal of Neural Transmission. General Section·A ThielE Rüther
Jul 24, 2013·Neurochemical Research·Adam PrzybyłkowskiAndrzej Członkowski
May 1, 1983·Psychiatry Research·D J LuchinsH Y Meltzer
Apr 1, 1993·Acta Neurologica Scandinavica·S KaakkolaJ Palo
Mar 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·L CunhaJ Pio-Abreu
Oct 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J J MannA Neophytides
Oct 16, 2010·Biomarkers in Medicine·Jakob NyhlénHenrik Zetterberg
Mar 1, 1995·The International Journal of Neuroscience·R Sandyk
Jan 1, 1990·The International Journal of Neuroscience·R Sandyk
Jan 1, 1990·The International Journal of Neuroscience·R Sandyk
Apr 15, 2000·The International Journal of Neuroscience·R P IaconoF H Nahab
Jan 1, 1979·The International Journal of Neuroscience·A C Cornwell
Sep 1, 2011·Progress in Neurobiology·Philippe HuotJonathan M Brotchie
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
Dec 17, 2009·Acta Neurologica Scandinavica·K IshibashiK Ishii
Jan 1, 1985·Annals of the New York Academy of Sciences·L J Thal
Feb 13, 2009·Expert Review of Neurotherapeutics·Yvette A M GrimbergenB R Bloem
Jul 1, 1982·Annals of Neurology·P J LanglaisW J McEntee
Feb 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L CunhaR Amaral
Nov 1, 1994·The International Journal of Neuroscience·R Sandyk
Apr 1, 1981·Acta Neurologica Scandinavica·M MarkianosC Sfagos

Related Concepts

Athetosis
Carbidopa, (S)-Isomer
Hereditary Chorea
Dihydroxyphenylalanine Hydrochloride, (2:1)
Intropin
Dystonia Musculorum Deformans
Hepatic Form of Wilson Disease
Homovanillic Acid
Hydroxyindoleacetic Acid
Levopa

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.