PMID: 591981Dec 1, 1977

CSF studies on the relationship between dopamine and 5-hydroxytryptamine in Parkinsonism and other movement disorders

Journal of Neurology, Neurosurgery, and Psychiatry
D DavidsonH Wilson


In Parkinson's disease, the concentration of homovanillic acid (HVA) was reduced in lumbar CSF from patients with idiopathic Parkinsonism (n = 54, P less than 0.05) and post-encephalitic Parkinsonism (n = 19, P less than 0.01). The reduction in the concentrations of 5-hydroxyindolylacetic acid (5-HIAA) was not significant, and there was no alteration in the levels of 4-hydroxy-3-methoxyphenylethylene glycol (MHPG). Treatment with L-dopa increased the concentration of HVA in the CSF (P less than 0.05) but had no effect on the levels of 5-HIAA and MHPG. Carbidopa given in combinations with L-dopa produced similar CSF concentrations of dopa as did L-dopa alone but caused less than half the rise in HVA. Fourteen patients who became functionally independent on treatment with L-dopa had higher 5-HIAA levels than 23 patients who showed no such improvement (P less than 0.001), suggesting that intact 5-hydroxyltryptamine neurones may be important in the therapeutic response to L-dopa. In a variety of movement disorders, the levels of HVA, 5-HIAA, and MHPG were not significantly different from age-matched controls. Treatment with tetrabenazine did not significantly alter the metabolite levels in patients in whom it produced either improv...Continue Reading


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Related Concepts

Carbidopa, (S)-Isomer
Hereditary Chorea
Dihydroxyphenylalanine Hydrochloride, (2:1)
Dystonia Musculorum Deformans
Hepatic Form of Wilson Disease
Homovanillic Acid
Hydroxyindoleacetic Acid

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