PMID: 8945737Nov 1, 1996Paper

CSF substance P somatostatin and monoaminergic transmitter metabolites in patients with narcolepsy

Neuroscience Letters
M StrittmatterK Schimrigk

Abstract

We have measured the concentrations of substance P, somatostatin, homovanillic acid (HVA), vanillyl mandelic acid (VMA) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) of six patients suffering from narcolepsy and 12 age- and gender-matched controls using high pressure liquid chromatography (HPLC) and radioimmunoassay (RIA). Substance P and somatostatin were significantly decreased in our patients compared to controls (36.9 +/- 9.1 fmol/ml versus 52.5 +/- 9.9 fmol/ml, P < 0.05 and 30.3 +/- 7.8 fmol/ml versus 43.9 +/- 9.8 fmol/ml, P < 0.05, respectively). 5-HIAA (P < 0.05) and VMA (P < 0.05) were also significantly decreased. HVA was significantly increased (P < 0.01). The CSF concentrations of substance P and somatostatin correlated with the clinical parameters duration of disease (r = -0.68, P < 0.05 and r = -0.72, P < 0.05, respectively) and severity of cataplectic symptoms (r = -0.71, P < 0.05 and r = -0.78, P < 0.01). In addition, substance P correlated with the intensity of sleepiness and the frequency of day-sleep attacks (r = -0.69, P < 0.05 and r = -0.68, P < 0.05, respectively). Substance P affects the amount of dopamine release in the nigra-striatal region, and decreased amounts could contribu...Continue Reading

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Citations

Feb 24, 2001·Mayo Clinic Proceedings·L E KrahnM H Silber
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·C FehrN Dahmen
Jul 4, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·S OvereemG J Lammers
Nov 17, 2009·Journal of Veterinary Internal Medicine·A Bathen-NöthenA Tipold
Jan 9, 2003·Pharmacogenomics·Mehdi Tafti, Yves Dauvilliers
Jul 5, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose E Martínez-Rodríguez, Joan Santamaria
Apr 16, 2008·Expert Opinion on Therapeutic Targets·Ahmet Ursavas
Oct 15, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Emmanuel BäckrydBjörn Gerdle
Aug 18, 2004·Behavioural Brain Research·Filipe S DuarteThereza C M De Lima

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