PMID: 9545494May 8, 1998Paper

CSF2RA, ANT3, and STS are autosomal in marsupials: implications for the origin of the pseudoautosomal region of mammalian sex chromosomes

Mammalian Genome : Official Journal of the International Mammalian Genome Society
R Toder, J A Graves

Abstract

The X and Y Chromosomes (Chrs) of eutherian ("placental") mammals share a pseudo-autosomal region (PAR) that pairs and recombines at meiosis. In humans and other eutherians, the PAR contains several active genes and has also been thought to be critical for pairing and fertility. In order to explore the origin of the PAR, we cloned and mapped three human or mouse pseudoautosomal genes in marsupials, a group of mammals that diverged from eutherians about 130 (MYrBP). All three genes were autosomal in marsupials, and two co-localized with other human Xp genes on an autosome. This implies that the human PAR, like most of human Xp, represents a relic of an autosomal region added to both X and Y Chrs between 80 and 150 MYrBP.

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Citations

Dec 27, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Chie MurataAsato Kuroiwa
Aug 31, 2001·ILAR Journal·Paul B. Samollow
Feb 5, 2003·Genome Research·Fadi J CharcharJennifer A Marshall Graves
Nov 7, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Janine E DeakinJennifer A Marshall Graves
May 1, 2012·Biochimica Et Biophysica Acta·Paulo Navarro-Costa
Oct 9, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Haig
Aug 8, 2007·The Journal of Biological Chemistry·Jeffrey V BrowerNaohiro Terada
Jun 16, 1999·Current Opinion in Obstetrics & Gynecology·P H Yen
Nov 5, 1999·Science·B T Lahn, D C Page

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