CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases

Cell Death & Disease
Min ZhaoHong Qu

Abstract

Cell senescence is a cellular process in which normal diploid cells cease to replicate and is a major driving force for human cancers and aging-associated diseases. Recent studies on cell senescence have identified many new genetic components and pathways that control cell aging. However, there is no comprehensive resource for cell senescence that integrates various genetic studies and relationships with cell senescence, and the risk associated with complex diseases such as cancer is still unexplored. We have developed the first literature-based gene resource for exploring cell senescence genes, CSGene. We complied 504 experimentally verified genes from public data resources and published literature. Pathway analyses highlighted the prominent roles of cell senescence genes in the control of rRNA gene transcription and unusual rDNA repeat that constitute a center for the stability of the whole genome. We also found a strong association of cell senescence with HIV-1 infection and viral carcinogenesis that are mainly related to promoter/enhancer binding and chromatin modification processes. Moreover, pan-cancer mutation and network analysis also identified common cell aging mechanisms in cancers and uncovered a highly modular netw...Continue Reading

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Citations

Dec 27, 2016·Ageing Research Reviews·Justin Cohen, Claudio Torres
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Jun 28, 2020·Kidney International·Yuliang WangStuart J Shankland

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Methods Mentioned

BETA
histone acetylation

Software Mentioned

Perl Script
BLAST
Reactome
cBio
ToppGene
house Perl script
My NCBI
CSGene
Linux
PathCommons

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