PMID: 25749381Mar 10, 2015Paper

CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression

Oncotarget
Qian ChengTan-Jun Tong

Abstract

Cellular senescence-inhibited gene (CSIG) protein significantly prolongs the progression of replicative senescence, but its role in tumorigenesis is unclear. To reveal the role of CSIG in HCC, we determined its expression in HCC tissues and surrounding tissues and its functions in tumor cell proliferation in vitro and in vivo. CSIG protein was overexpressed in 86.4% of the human HCC cancerous tissues as compared with matched surrounding tissues, and its protein expression was greater in HCC cells than the non-transformed hepatic cell line L02. Furthermore, upregulation of CSIG significantly increased the colony formation of SMMC7721 and HepG2 cells, and silencing CSIG could induce cell cycle arrest and cell apoptosis. The tumorigenic ability of CSIG was confirmed in vivo in a mouse xenograft model. Our results showed that CSIG promoted the proliferation of HepG2 and SMMC7721 cells in vivo. Finally, CSIG protein directly interacted with c-MYC protein and increased c-MYC protein levels; the ubiquitination and degradation of c-MYC protein was increased with knockdown of CSIG. CSIG could also increase the expression of c-MYC protein in SMMC7721 cells in vivo, and it was noted that the level of c-MYC protein was also elevated in mos...Continue Reading

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Citations

Sep 14, 2017·International Journal of Oncology·Caijie LuMingyi Li
Jan 18, 2018·Epigenomics·Licong ShenYi Zhang
Aug 8, 2021·Journal of Experimental & Clinical Cancer Research : CR·Li DingXinyue Zhang

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