C(sp2 )-H Trifluoromethylation of enamides using TMSCF3 : access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

Chemical Communications : Chem Comm
Vinayak KrishnamurtiG K Surya Prakash

Abstract

A method for the direct C(sp2)-H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.

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Citations

May 24, 2019·Chemical Communications : Chem Comm·Shaoke ZhangMatthias Beller
Nov 14, 2020·Chemical Communications : Chem Comm·Shuguang ZhouTeck-Peng Loh

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Methods Mentioned

BETA
amidation

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