CT- and ultrasound-characteristics of hepatic lesions in patients with multiple endocrine neoplasia syndrome. A retrospective image review of 25 cases

PloS One
Nassim FardBjörn Jobke

Abstract

Liver metastases from neuroendocrine tumors in multiple endocrine neoplasia syndrome are common (75%) and significantly impairs the prognosis. Characterisation of liver lesions in these patients is challenging, as liver metastases are difficult to differentiate from benign liver lesions such as haemangioma. In this study we aimed to characterize the radiological findings of hepatic metastases in MEN patients. The findings of contrast-enhanced CT were considered for the main diagnosis. We retrospectively evaluated 25 patients with MEN-syndrome (10 MEN1/ 15 MEN2) including 11 men and 14 women between 28-62 years of age. Liver metastases (48%, 12/25) and hemangioma (40%, 10/25) were the most common liver lesions among our patients. The most common primary tumors in our MEN1 and MEN2 patients with liver metastases were of pancreatic neuroendocrine tumor (70%, 7/10) und medullary thyroid carcinoma (100%, 15/15) origin, respectively. CT-characteristics were grouped into three main categories, depending on contrast dynamics. The majority of hepatic metastases (75%, 14/25) are presented as multiple lesions with a slow growth in an average 5 years of follow-up-period. We were able to find a common CT pattern and categorise these for eac...Continue Reading

References

Jan 1, 1985·Seminars in Roentgenology·J L Doppman
Nov 1, 1987·Journal of Computer Assisted Tomography·M S BankoffD Scarborough
Nov 1, 1986·Journal of Computer Assisted Tomography·C H McDonnellE A Zerhouni
May 1, 1996·Journal of Computer Assisted Tomography·J F BergerE Schouman-Claeys
Jan 23, 1998·European Journal of Endocrinology·H M Heshmati, L C Hofbauer
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·R V Thakker
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·M L BrandiS J Marx
Dec 20, 2002·International Journal of Gastrointestinal Cancer·J L Fidler, C D Johnson
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P SzavcsurO Esik
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andrew F ScarsbrookRachel R Phillips
Apr 13, 2006·The Journal of Clinical Endocrinology and Metabolism·J FromiguéM Schlumberger
Jun 6, 2007·Hematology/oncology Clinics of North America·Eric P TammChaan S Ng
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Douglas W Ball
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Anne Laure GiraudetMartin Schlumberger
Dec 17, 2008·Neuroendocrinology·Anders SundinUNKNOWN European Neuroendocrine Tumor Society
Jan 21, 2010·Familial Cancer·Friedhelm Raue, Karin Frank-Raue
Sep 16, 2011·Clinical Endocrinology·William F SimondsLynnette K Nieman
Oct 21, 2011·International Journal of Hepatology·Theresa R HarringChristine A O'Mahony
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Rajesh V ThakkerUNKNOWN Endocrine Society
Jun 26, 2013·Diagnostic and Interventional Imaging·T KlotzJ-M Garcier
Nov 23, 2013·AJR. American Journal of Roentgenology·Dhakshinamoorthy GaneshanChusilp Charnsangavej
Dec 21, 2013·Journal of Clinical Gastroenterology·Sharlene L DʼsouzaJames M Scheiman
Apr 1, 2012·European Thyroid Journal·M SchlumbergerUNKNOWN European Thyroid Association Task Force
Mar 13, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Michael S HofmanRodney J Hicks
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Dec 19, 2016·Annales d'endocrinologie·Anne-Laure Giraudet, David Taïeb
Feb 16, 2018·Clinical Imaging·Giuseppe CorriasLorenzo Mannelli
Feb 28, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiIrvin M Modlin
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Luciana Audi CastronevesAna Oliveira Hoff
Aug 29, 2018·Neuroendocrinology·Jaume CapdevilaUNKNOWN ENETS 2016 Munich Advisory Board Participants

❮ Previous
Next ❯

Citations

Aug 2, 2019·Der Radiologe·M Uhrig, S Delorme

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
biopsy
imaging techniques

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Carcinoma, Islet Cell (Keystone)

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arise in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on islet cell carcinoma in this feed.

Carcinoma, Islet Cell

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arises in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Carcinoma here.