CT appearances and prognostic significance of splenic metastasis in ovarian cancer

Clinical Radiology
N J SpencerG Lane

Abstract

A retrospective review of women undergoing computed tomography (CT) as part of the investigation and management of pathologically proven ovarian cancer in a single specialist gynaecological cancer centre. To ascertain CT appearances and prognostic significance of splenic involvement in ovarian cancer. We found a 10.3% frequency of splenic metastasis in a series of 321 patients with ovarian cancer. Thirty-three women had splenic metastases demonstrated on CT. Twenty-three women had surface lesions with an irregular scalloped shape and broad contact with the splenic surface; 17 of these women had lesions at presentation. Ten women had parenchymal lesions, five at presentation and five at relapse, typically with a rounded shape surrounded by normal splenic tissue. Four out of 10 cases with parenchymal involvement showed lesion progression during chemotherapy. However, lesion progression occurred in only one of 23 cases with surface disease (P < 0.025, Fisher's exact test). In 16 cases with disease involving both spleen and liver, the response to chemotherapy was the same in both organs. We have found a higher frequency of splenic metastasis from ovarian cancer during life than previously reported. Parenchymal lesions are significa...Continue Reading

References

Nov 1, 1991·Gynecologic Oncology·M MorrisF N Rutledge
Apr 1, 1991·Gynecologic Oncology·B Patsner, P G Rose
Jun 1, 1990·Clinical Radiology·B M CarringtonR J Johnson
Dec 1, 1989·Gynecologic Oncology·E W SonnendeckerK A Margolius
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Aug 1, 1993·Clinical Radiology·R J Johnson

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Citations

May 15, 2016·Clinical Imaging·Zina J RicciFernanda S Mazzariol
Feb 21, 2006·Pathology, Research and Practice·Corinna Ariane SchönPeter J Barth
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charlie GourleyMichelle Ferguson
Mar 29, 2014·Experimental and Therapeutic Medicine·Meiling LvJin Yang
Mar 29, 2011·European Journal of Radiology·Senem SenturkDeniz Akata

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