CT-based peritumoral radiomics signatures to predict early recurrence in hepatocellular carcinoma after curative tumor resection or ablation

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Quan-Yuan ShanMing Kuang

Abstract

To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative treatment. In total, 156 patients with primary HCC were randomly divided into the training cohort (109 patients) and the validation cohort (47 patients). From the pretreatment CT images, we extracted 3-phase two-dimensional images from the largest cross-sectional area of the tumor. A region of interest (ROI) was manually delineated around the lesion for tumoral radiomics (T-RO) feature extraction, and another ROI was outlined with an additional 2 cm peritumoral area for peritumoral radiomics (PT-RO) feature extraction. The least absolute shrinkage and selection operator (LASSO) logistic regression model was applied for feature selection and model construction. The T-RO and PT-RO models were constructed. In the validation cohort, the prediction efficiencies of the two models and peritumoral enhancement (PT-E) were evaluated qualitatively by receiver operating characteristic (ROC) curves, calibration curves and decision curves and quantitatively by area under the curve (AUC), the category-free net reclassification index (cfNRI) ...Continue Reading

References

Aug 1, 2007·World Journal of Gastroenterology : WJG·Rong TuLing Wu
Oct 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zhi Li WangDe Jiang Yu
Dec 21, 2007·AJR. American Journal of Roentgenology·Akihiro NishieHiroshi Honda
Nov 28, 2008·BMC Medical Informatics and Decision Making·Andrew J VickersMithat Gonen
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles CoutantRoman Rouzier
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Aug 26, 2014·AJR. American Journal of Roentgenology·Chen-Te ChouYao-Li Chen
Nov 26, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Zhangjun ChengFeng Shen
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix

❮ Previous
Next ❯

Citations

Sep 19, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Marta BogowiczStephanie Tanadini-Lang
Jun 10, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Jingwei WeiJie Tian
Jun 4, 2020·Current Opinion in Organ Transplantation·Tommy IvanicsGonzalo Sapisochin
Jul 25, 2020·The British Journal of Radiology·Thomas Helmberger
Jun 26, 2020·Cancer Management and Research·Tao ZhangXiuwen Chen
Jan 12, 2020·Abdominal Radiology·Sara LewisBachir Taouli
Apr 17, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Constantin DreherBettina Baessler
Mar 21, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyo Jung ParkSeung Soo Lee
Feb 26, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Pei NieWenjian Xu
Nov 11, 2019·Abdominal Radiology·Joao Manoel Miranda Magalhaes SantosNatally Horvat
Jan 24, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Qiu-Ping MaJei Tian
Dec 4, 2020·World Journal of Gastroenterology : WJG·Quirino LaiMassimo Rossi
Jan 29, 2021·Cardiovascular and Interventional Radiology·Marjaneh TaghaviMonique Maas
Mar 13, 2021·Journal of Gastroenterology and Hepatology·Yu Sub SungSeung Soo Lee
Mar 14, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Lise WeiIssam El Naqa
Jul 24, 2021·Journal of Computer Assisted Tomography·Linda C ChuElliot K Fishman
Aug 15, 2021·Alimentary Pharmacology & Therapeutics·Emily Harding-TheobaldNeehar D Parikh

❮ Previous
Next ❯

Methods Mentioned

BETA
feature extractions
feature extraction

Software Mentioned

R “
PT
pROC
LASSO
PredictABEL
knnImputation
R
R Foundation for Statistical Computing
CalibrationCurves
nricens ”

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.