CT-Based Radiomics Signature With Machine Learning Predicts MYCN Amplification in Pediatric Abdominal Neuroblastoma.

Frontiers in Oncology
Xin ChenLing He

Abstract

MYCN amplification plays a critical role in defining high-risk subgroup of patients with neuroblastoma. We aimed to develop and validate the CT-based machine learning models for predicting MYCN amplification in pediatric abdominal neuroblastoma. A total of 172 patients with MYCN amplified (n = 47) and non-amplified (n = 125) were enrolled. The cohort was randomly stratified sampling into training and testing groups. Clinicopathological parameters and radiographic features were selected to construct the clinical predictive model. The regions of interest (ROIs) were segmented on three-phrase CT images to extract first-, second- and higher-order radiomics features. The ICCs, mRMR and LASSO methods were used for dimensionality reduction. The selected features from the training group were used to establish radiomics models using Logistic regression, Support Vector Machine (SVM), Bayes and Random Forest methods. The performance of four different radiomics models was evaluated according to the area under the receiver operator characteristic (ROC) curve (AUC), and then compared by Delong test. The nomogram incorporated of clinicopathological parameters, radiographic features and radiomics signature was developed through multivariate lo...Continue Reading

References

Aug 27, 2005·IEEE Transactions on Pattern Analysis and Machine Intelligence·Hanchuan PengChris Ding
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L CohnUNKNOWN INRG Task Force
Sep 24, 2011·AJR. American Journal of Roentgenology·Michael D Kuo, Shota Yamamoto
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kieuhoa T VoSteven G DuBois
May 2, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sudeep BanerjeeMichael D Kuo
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navin R PintoSusan L Cohn
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Feb 18, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Bradley J EricksonTimothy L Kline
Nov 22, 2017·Journal of Magnetic Resonance Imaging : JMRI·Emma M MeeusAndrew C Peet
Nov 28, 2018·Pediatric Blood & Cancer·Daniel A MorgensternMeredith S Irwin
Dec 14, 2018·AJNR. American Journal of Neuroradiology·M IvK W Yeom
Jan 20, 2019·Children·Kyle J Van Arendonk, Dai H Chung
Feb 14, 2019·Children·Elizabeth Sokol, Ami V Desai
Oct 18, 2019·Pediatric Radiology·Katharine E Orr, Kieran McHugh
Nov 7, 2019·Journal of Pediatric Surgery·David YanishevskiAndrew M Davidoff
May 21, 2020·Current Hematologic Malignancy Reports·Saman KhanAmmar Chaudhry
Sep 12, 2020·AJNR. American Journal of Neuroradiology·A LasockiK J Drummond

❮ Previous
Next ❯

Software Mentioned

mRMR
AK
Artificial Intelligence Kit , AK
R
LogitBoost
ITK
mRMRe
glmnet
LASSO
pROC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.