CT-based tissue segmentation to assess knee joint inflammation and reactive bone formation assessed by 18 F-FDG and 18 F-NaF PET/CT: Effects of age and BMI

Hellenic journal of nuclear medicine
Abdullah Al-ZaghalAbass Alavi

Abstract

This study was conducted to determine the role of computed tomography (CT)-based segmentation methodology to semi-quantify the degree of inflammation and reactive bone formation in the knee joints by fluorine-18-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride positron emission tomography/CT (18F-NaF PET/CT) imaging, respectively. Furthermore, we assessed the impact of aging and body mass index (BMI) on these biological responses. In this retrospective study, we examined a total of 97 subjects who had undergone both 18F-FDG and 18F-NaF PET/CT scanning. The mean age was 49.3±14.9 (21-75) and the mean BMI was 26.7±4.3 (17.7-42.0). Whole joint compartments and osseous compartments were segmented on fused PET/CT images using a 3D-growing algorithm with an adjustable upper/lower Hounsfield Units (HU) thresholds and manual tools. The metabolic activity and volume of each compartment was measured, values from the osseous compartment were subtracted from the whole joint to get the volume and metabolic activity of the soft tissue. The metabolic activity was correlated with age and BMI. Fluorine-18-FDG uptake in the soft tissues surrounding the joint was 0.35±0.07 while 0.19±0.04 in the osseous structures (P<0.0001). Aging positively...Continue Reading

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