CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study

Radiology
David A LynchGenetic Epidemiology of COPD (COPDGene) Investigators

Abstract

Purpose To determine whether visually assessed patterns of emphysema at CT might provide a simple assessment of mortality risk among cigarette smokers. Materials and Methods Of the first 4000 cigarette smokers consecutively enrolled between 2007 and 2011 in this COPDGene study, 3171 had data available for both visual emphysema CT scores and survival. Each CT scan was retrospectively visually scored by two analysts using the Fleischner Society classification system. Severity of emphysema was also evaluated quantitatively by using percentage lung volume occupied by low-attenuation areas (voxels with attenuation of -950 HU or less) (LAA-950). Median duration of follow-up was 7.4 years. Regression analysis for the relationship between imaging patterns and survival was based on the Cox proportional hazards model, with adjustment for age, race, sex, height, weight, pack-years of cigarette smoking, current smoking status, educational level, LAA-950, and (in a second model) forced expiratory volume in 1 second (FEV1). Results Observer agreement in visual scoring was good (weighted κ values, 0.71-0.80). There were 519 deaths in the study cohort. Compared with subjects who did not have visible emphysema, mortality was greater in those wi...Continue Reading

References

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Citations

Aug 29, 2018·Radiology·Daniel K Powell
Feb 15, 2019·Expert Review of Respiratory Medicine·Rob JanssenEmiel F M Wouters
Jan 7, 2020·The Clinical Respiratory Journal·Chun Geun LimSeung-Ick Cha
Dec 4, 2019·Radiology·Stephen M HumphriesUNKNOWN Genetic Epidemiology of COPD (COPDGene) Investigators
Apr 15, 2020·AIDS·Ken M KunisakiAlison Morris
Nov 15, 2019·The British Journal of Radiology·Hendrik Joost WisselinkRozemarijn Vliegenthart
Jul 8, 2020·Radiology·Andrea S OhUNKNOWN Genetic Epidemiology of COPDGene Investigators
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Apr 17, 2019·Clinical and Translational Medicine·Lukasz A MycJulien Dimastromatteo
May 3, 2020·Respiratory Research·Mariaelena OcchipintiMassimo Pistolesi
Dec 20, 2018·Respiratory Research·Surya P BhattUNKNOWN SPIROMICS investigators
Feb 17, 2021·Radiology·Samuel Y AshUNKNOWN COPDGene Investigators and the COPD Biomarker Qualification Consortium
Feb 18, 2021·Radiology·Kyung Soo Lee, Hye Yun Park
Jan 8, 2021·Spatial Statistics·Brian E VestalDebashis Ghosh
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Nov 13, 2020·American Journal of Respiratory and Critical Care Medicine·Eleanor M DunicanJohn V Fahy
Apr 23, 2021·Respiratory Investigation·Naoya TanabeToyohiro Hirai
Jun 26, 2020·European Journal of Radiology·Xianxian CaoYoumin Guo
Jun 30, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christine R Jenkins
Aug 26, 2021·PloS One·Lucas A GillenwaterKaterina J Kechris
Sep 15, 2021·Radiology·Philippe A Grenier
Nov 19, 2019·Respiratory Medicine·Sarah Marietta von SiemensUNKNOWN Names of participating study nurses

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Clinical Trials Mentioned

NCT00608764

Software Mentioned

3DSlicer
SAS
COPDGene

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