CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon

PloS One
Luiz Fábio Magno FalcãoJ A S Quaresma

Abstract

The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0.000), including more frequent bronchiectasis (P = 0.049), parenchymal bands (P = 0.007), interlobular septal thickening (P = 0.035), and pleural thickening (P = 0.009). In addition, neither patients with HAM/TSP (9/30; 30%) nor the controls (0/18; 0%) had obstructive or restrictive lung disease (P = 0.009). HTLV diagnosis should be considered in all patients with abnormal CT findings in whom no other cause is apparent. It is important to remember that lung disease increases the rates of morbidity and mortality in developing countries.

Associated Clinical Trials

References

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Citations

Feb 16, 2020·Retrovirology·Ricardo IshakAntonio Carlos R Vallinoto
Aug 30, 2018·Frontiers in Microbiology·Apio R N DiasJuarez A S Quaresma
Sep 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lloyd EinsiedelJohn Kaldor
Nov 3, 2020·Virus Evolution·Ricardo IshakAntonio Carlos Rosário Vallinoto
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Carolina RosadasRicardo Ishak
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Carolina RosadasRicardo Ishak
Dec 30, 2021·PloS One·Apio Ricardo Nazareth DiasJuarez Antônio Simões Quaresma

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
bronchoalveolar lavage

Software Mentioned

Imac
GraphPad Prism
OsiriX MD

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