CT cholangiography in potential liver donors: effect of premedication with intravenous morphine on biliary caliber and visualization

Radiology
Richard S BreimanBenjamin M Yeh

Abstract

To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography. This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52% diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization). For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P > .39 for both readers), in common bile duct area (20.7 vs 21.5 mm(2), for reader 1 and 21.3 vs 20....Continue Reading

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Citations

Apr 23, 2011·Transplantation·Hsien-Wen HsuYu-Fan Cheng
Jan 23, 2010·AJR. American Journal of Roentgenology·Patric KröpilDirk Blondin
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Benjamin M YehHero K Hussain
Nov 11, 2008·The Surgical Clinics of North America·Christoph WaldSebastian Flacke
Jun 1, 2013·Journal of Magnetic Resonance Imaging : JMRI·Mukta D AgrawalMartin R Prince
Oct 19, 2013·Experimental and Therapeutic Medicine·Yunbao XiaChengjun Geng

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