CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): an open-label, parallel-group, multicentre trial

Lancet
SCOT-HEART investigators

Abstract

The benefit of CT coronary angiography (CTCA) in patients presenting with stable chest pain has not been systematically studied. We aimed to assess the effect of CTCA on the diagnosis, management, and outcome of patients referred to the cardiology clinic with suspected angina due to coronary heart disease. In this prospective open-label, parallel-group, multicentre trial, we recruited patients aged 18-75 years referred for the assessment of suspected angina due to coronary heart disease from 12 cardiology chest pain clinics across Scotland. We randomly assigned (1:1) participants to standard care plus CTCA or standard care alone. Randomisation was done with a web-based service to ensure allocation concealment. The primary endpoint was certainty of the diagnosis of angina secondary to coronary heart disease at 6 weeks. All analyses were intention to treat, and patients were analysed in the group they were allocated to, irrespective of compliance with scanning. This study is registered with ClinicalTrials.gov, number NCT01149590. Between Nov 18, 2010, and Sept 24, 2014, we randomly assigned 4146 (42%) of 9849 patients who had been referred for assessment of suspected angina due to coronary heart disease. 47% of participants had a...Continue Reading

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Citations

Feb 20, 2016·Journal of the American College of Cardiology·Christopher B FordycePamela S Douglas
Feb 13, 2016·Journal of Interventional Cardiology·Cindy L GrinesTheodore L Schreiber
Jan 20, 2016·Current Cardiology Reports·Mhairi Doris, David E Newby
Jan 23, 2016·Revista Española De Cardiología·Manuel Martínez-SellésJosé Ángel Rodríguez
Jan 5, 2016·European Heart Journal·Oliver GaemperliJeroen J Bax
Jan 12, 2016·Revista Española De Cardiología·Teresa López-FernándezJoaquín Barba-Cosials
Jan 13, 2016·Journal of Cardiovascular Computed Tomography·Julia StehliPhilipp A Kaufmann
Mar 8, 2016·Revista Española De Cardiología·Iván J Núñez-GilRosa María Lidón
Oct 18, 2015·Journal of the American College of Cardiology·Edward Hulten, Marcelo F Di Carli
Oct 18, 2015·Journal of the American College of Cardiology·Mark A HlatkyUNKNOWN PLATFORM Investigators
Dec 25, 2015·JACC. Cardiovascular Imaging·David E Newby, Alasdair J Gray
Nov 6, 2015·Cardiology and Therapy·Peter McKavanaghPatrick M Donnelly
Mar 20, 2015·Lancet·Pamela S Douglas
Nov 23, 2015·Cardiology Clinics·Alan Rozanski, Daniel S Berman
Sep 18, 2015·European Heart Journal Cardiovascular Imaging·Khaled Alfakih, Sven Plein
Jan 31, 2016·Heart·Christopher B Fordyce, Pamela S Douglas
May 12, 2015·Journal of Cardiovascular Computed Tomography·Ricardo C Cury
Apr 7, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Seth UretskyAlan Rozanski
Aug 10, 2015·Journal of Cardiovascular Computed Tomography·Jonathon A Leipsic
Apr 16, 2016·Journal of the American College of Cardiology·Michelle C WilliamsUNKNOWN SCOT-HEART Investigators
Apr 16, 2016·Journal of the American College of Cardiology·James K MinJessica M Peña
Apr 14, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Márcio Sommer Bittencourt, Ron Blankstein
Jun 21, 2015·Current Treatment Options in Cardiovascular Medicine·Joshua Schulman-MarcusQuynh A Truong
Apr 20, 2016·Clinical Radiology·M C Williams, D E Newby
Oct 27, 2015·Current Cardiovascular Imaging Reports·Amir Ali Rahsepar, Armin Arbab-Zadeh
Jun 9, 2015·Journal of Cardiovascular Computed Tomography·Ricardo C Cury
May 31, 2015·Journal of Cardiovascular Computed Tomography·Udo Hoffmann, Pamela S Douglas
May 4, 2016·Expert Review of Medical Devices·Ayaz AghayevMichael Steigner
Apr 23, 2016·Scandinavian Cardiovascular Journal : SCJ·Juuso I BlomsterClara K Chow
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Jun 16, 2016·Lancet·Anoop S V ShahUNKNOWN High-STEACS Investigators
Jun 10, 2016·Cardiology and Therapy·Claire McCuneIan B A Menown

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