CT Features of Ovarian Tumors: Defining Key Differences Between Serous Borderline Tumors and Low-Grade Serous Carcinomas

AJR. American Journal of Roentgenology
Stephanie NougaretEvis Sala

Abstract

The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profiled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantified total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses. Univariate and multivariate associations of the CT features with histopathologic diagnoses and mutations were evaluated, and interreader agreement was determined. At multivariate analysis, the presence of bilateral ovarian masses (p = 0.03), the presence of peritoneal disease (PD) (p = 0.002), and higher STV of ovarian masses (p = 0.002) were associated with LGSC. The presence of nodular PD pattern (p < 0.001 each reader) and the presence of PD calcifications (reader 1, p = 0.02; reader 2, p = 0.003) were associated with invasive peritoneal lesions (i.e., LGSC). The presence of bilateral ovarian...Continue Reading

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Citations

Dec 19, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Elizabeth A GouldingPeter Sykes
Apr 5, 2020·Japanese Journal of Radiology·Masaya KawaguchiMasayuki Matsuo
Nov 19, 2019·Journal of Computer Assisted Tomography·Sherif B ElsherifPriya R Bhosale
Sep 19, 2018·Current Treatment Options in Oncology·Rachel N Grisham, Gopa Iyer
Feb 1, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·C Abdel WahabI Thomassin-Naggara
May 12, 2021·Insights Into Imaging·Sofia AmanteTeresa Margarida Cunha
Jun 6, 2021·Abdominal Radiology·Sherif B ElsherifDhakshinamoorthy Ganeshan
Jun 12, 2021·The British Journal of Radiology·Hilal SahinHelen Addley
Aug 20, 2021·European Journal of Radiology·Ana Sofia AlvesTeresa Margarida Cunha

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