CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis

AJR. American Journal of Roentgenology
Masanori AkiraS Yamamoto

Abstract

Most patients with idiopathic pulmonary fibrosis (IPF) show slowly progressive deterioration. However, accelerated deterioration also occurs in patient with IPF who have previously shown slowly progressive deterioration. The purpose of this study was to evaluate the CT findings of accelerated deterioration in patients with IPF. We evaluated the CT findings of 17 patients with IPF who fulfilled all the following criteria for accelerated deterioration of IPF: exacerbation of dyspnea within 1 month, new diffuse pulmonary opacities on chest radiography, a decrease in arterial oxygen tension (PaO2) of more than 10 mm Hg under similar conditions, and absence of apparent infectious agents and heart failure. Seven patients underwent sequential CT examination. Pathologic specimens were obtained from nine patients. CT findings were classified as peripheral parenchymal opacification (n = 6), multifocal parenchymal opacification (n = 6), and diffuse parenchymal opacification (n = 5). Multifocal lesions developed diffusely in two of the seven patients who underwent sequential CT. These two patients both died. Three of the six patients with a multifocal pattern responded to corticosteroid therapy. All patients with a peripheral pattern showe...Continue Reading

Citations

Aug 9, 2011·European Radiology·Kiminori FujimotoNestor L Müller
Nov 29, 2012·General Thoracic and Cardiovascular Surgery·Atsushi WatanabeTetsuya Higami
Feb 14, 2004·European Journal of Radiology·Olivier BonnefoyFrançois Laurent
Dec 24, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Payal N NaikBethany B Moore
May 18, 2010·Current Opinion in Pulmonary Medicine·Ilias C PapanikolaouVlasis S Polychronopoulos
Sep 19, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hiromi TomiokaHironobu Iwasaki
Sep 11, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robert Matthew KottmannPatricia J Sime
Dec 2, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kazutoshi IsobeSakae Homma
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tristan J HuieStephen K Frankel
Jul 29, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tamera J Corte, Athol U Wells
Jun 4, 2011·Pulmonary Medicine·Riitta Kaarteenaho, Vuokko L Kinnula
Jun 4, 2011·Pulmonary Medicine·Atsushi WatanabeTetsuya Higami
Jun 5, 2008·American Journal of Respiratory and Critical Care Medicine·Arata AzumaShoji Kudoh
Mar 29, 2003·American Journal of Respiratory and Critical Care Medicine·Isabelle HonoréBruno Crestani
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Kevin R FlahertyFernando J Martinez
Jan 25, 2005·American Journal of Respiratory and Critical Care Medicine·Arata AzumaShoji Kudoh
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·Hiromitsu SumikawaNestor L Müller
Jun 19, 2007·American Journal of Respiratory and Critical Care Medicine·Jason H T BatesBéla Suki
Jun 23, 2007·American Journal of Respiratory and Critical Care Medicine·Harold R CollardUNKNOWN Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators
May 3, 2008·American Journal of Respiratory and Critical Care Medicine·Masanori AkiraMitsunori Sakatani
Apr 14, 2009·American Journal of Respiratory and Critical Care Medicine·Kazuhisa KonishiNaftali Kaminski
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jan 3, 2012·American Journal of Respiratory and Critical Care Medicine·Brett Ley, Harold R Collard
Aug 24, 2013·Respiratory Research·Dong Soon Kim
Mar 28, 2008·Orphanet Journal of Rare Diseases·Eric B Meltzer, Paul W Noble
Nov 19, 2008·Fibrogenesis & Tissue Repair·Kevin M Vannella, Bethany B Moore
Jan 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Spyros A PapirisCharis Roussos
May 23, 2003·American Journal of Clinical Pathology·Alexandra J RiceAndrew G Nicholson
Jun 2, 2006·Proceedings of the American Thoracic Society·Dong Soon KimTalmadge E King
Dec 17, 2005·Internal Medicine·Sakae HommaKunihiko Yoshimura
May 8, 2009·Internal Medicine·Yuji MinegishiAkihiko Gemma
Jan 16, 2010·Internal Medicine·Susumu SakamotoKunihiko Yoshimura
Mar 24, 2011·AJR. American Journal of Roentgenology·Hiroaki Arakawa, Koichi Honma
Aug 23, 2001·AJR. American Journal of Roentgenology·E A Kazerooni
May 27, 2010·Radiology·Jeffrey R GalvinTeri J Franks
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.